Cayman Chemical Item Number 13357

WIN 47,203; Primacor® (CAS 78415-72-2)

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Phosphodiesterase 3 (PDE3) family members have high-affinities for both cAMP and cGMP and show cGMP-dependent inhibition of cAMP hydrolysis. Milrinone is a potent inhibitor of type 3 phosphodiesterases (PDEs), inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1.0 μM, respectively.1 It less effectively inhibits other PDE isoforms, with IC50 values of 263, >300, 17.5, 49.1, and 58.3 μM for PDE1, PDE2, PDE4, PDE5, and PDE7, respectively.1 Milrinone has positive inotropic (stimulates cardiac muscle contractions) and vasodilatory effects when administered in vivo.2,3,4

1. Sudo, T., Tachibana, K., Toga, K., et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phophodiesterase isozyme activity. Biochem Pharmacol 59 347-56 (2000).

2. Lakshminrusimha, S., Porta, N.F.M., Farrow, K.N., et al. Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn. Pediatr Crit Care Med 10(1) 106-12 (2009).

3. Simkova, V., Radermacher, P., and Barth, E. Metabolic effects of phophodiesterase III inhibitors: Another reason to promote their use? Crit Care 11(3) (2007).

4. Maskin, C.S., Sinoway, L., Chadwick, B., et al. Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart failure. Circ J 67 1065-70 (1983).

  • WIN 47,203
  • Primacor®
Formal Name 1,​6-​dihydro-​2-​methyl-​6-​oxo-​[3,​4'-​bipyridine]-​5-​carbonitrile
CAS Number 78415-72-2
Molecular Formula C12H9N3O
Formula Weight 211.2
Formulation A crystalline solid
Purity ≥98%
λmax 214, 270, 344 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
5 mg $65.00 $0.00
10 mg $124.00 $0.00
50 mg $520.00 $0.00
100 mg $910.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-01. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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