Milrinone

Cayman Chemical Item Number 13357

WIN 47,203; Primacor® (CAS 78415-72-2)

Milrinone (CAS 78415-72-2)

See more

Description

Phosphodiesterase 3 (PDE3) family members have high-affinities for both cAMP and cGMP and show cGMP-dependent inhibition of cAMP hydrolysis. Milrinone is a potent inhibitor of PDE3s, inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1.0 μM, respectively.1 It less effectively inhibits other PDE isoforms, with IC50 values of 263, >300, 17.5, 49.1, and 58.3 μM for PDE1, PDE2, PDE4, PDE5, and PDE7, respectively.1 Milrinone has positive inotropic (stimulates cardiac muscle contractions) and vasodilatory effects when administered in vivo.2,3,4

1 Sudo, T., Tachibana, K., Toga, K., et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phophodiesterase isozyme activity. Biochem Pharmacol 59 347-56 (2000).

2 Lakshminrusimha, S., Porta, N.F.M., Farrow, K.N., et al. Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn. Pediatr Crit Care Med 10(1) 106-12 (2009).

3 Simkova, V., Radermacher, P., and Barth, E. Metabolic effects of phophodiesterase III inhibitors: Another reason to promote their use? Crit Care 11(3) (2007).

4 Maskin, C.S., Sinoway, L., Chadwick, B., et al. Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart failure. Circ J 67 1065-70 (1983).

Synonyms
  • WIN 47,203
  • Primacor®
Formal Name 1,​6-​dihydro-​2-​methyl-​6-​oxo-​[3,​4'-​bipyridine]-​5-​carbonitrile
CAS Number 78415-72-2
Molecular Formula C12H9N3O
Formula Weight 211.2
Formulation A crystalline solid
Purity ≥98%
λmax 214, 270, 344 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O=C(C(C#N)​=C1)​NC(C)​=C1C2=CC=NC=C2
InCHI Code
Copy InCHI code to clipboard
​1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)​6-10(7-13)​12(16)​15-8/h2-6H,1H3,(H,15,16)​
InCHI Key
Copy InCHI key to clipboard
PZRHRDRVRGEVNW-UHFFFAOYSA-N

Download free InCHI Key generation software

Size Price Quantity Subtotal
5 mg $65.00 $0.00
10 mg $124.00 $0.00
50 mg $520.00 $0.00
100 mg $910.00 $0.00
Bulk Contact
Cart Total $0.00

Please Login or Register to use this page.

Pricing updated 2014-04-17. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

Cilostamide
Cyclic AMP EIA Kit
Cyclic GMP EIA Kit
EHNA (hydrochloride)
IBMX
Rolipram
Show all 6 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Other Resources
About Cayman Management Team Company Profile ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map Conference Travel Grants

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2014 Cayman Chemical Company

Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research · Buy now! · Analytical testing services and custom synthesis also available

Lost password?