Item № 13357
CAS № 78415-72-2
Purity ≥98%
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5 mg $65.00 $0.00
10 mg $124.00 $0.00
50 mg $520.00 $0.00
100 mg $910.00 $0.00

Pricing updated 2015-11-25. Prices are subject to change without notice.

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  • WIN 47,203
  • Primacor®

Phosphodiesterase 3 (PDE3) family members have high-affinities for both cAMP and cGMP and show cGMP-dependent inhibition of cAMP hydrolysis. Milrinone is a potent inhibitor of type 3 phosphodiesterases (PDEs), inhibiting recombinant PDE3A and PDE3B with IC50 values of 0.45 and 1.0 μM, respectively.1 It less effectively inhibits other PDE isoforms, with IC50 values of 263, >300, 17.5, 49.1, and 58.3 μM for PDE1, PDE2, PDE4, PDE5, and PDE7, respectively.1 Milrinone has positive inotropic (stimulates cardiac muscle contractions) and vasodilatory effects when administered in vivo.2,3,4

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Technical Information
Formal Name 1,6-dihydro-2-methyl-6-oxo-[3,4'-bipyridine]-5-carbonitrile
CAS Number 78415-72-2
  • WIN 47,203
  • Primacor®
Molecular Formula C12H9N3O
Formula Weight 211.2
Purity ≥98%
Formulation A crystalline solid
λmax 214, 270, 344 nm
InChI Code 1S/C12H9N3O/c1-8-11(9-2-4-14-5-3-9)6-10(7-13)12(16)15-8/h2-6H,1H3,(H,15,16)

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 99 Kb PDF

Download Safety Data Sheet (SDS) 27 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Sudo, T., Tachibana, K., Toga, K., et al. Potent effects of novel anti-platelet aggregatory cilostamide analogues on recombinant cyclic nucleotide phophodiesterase isozyme activity. Biochem Pharmacol 59 347-56 (2000).

2. Lakshminrusimha, S., Porta, N.F.M., Farrow, K.N., et al. Milrinone enhances relaxation to prostacyclin and iloprost in pulmonary arteries isolated from lambs with persistent pulmonary hypertension of the newborn. Pediatr Crit Care Med 10(1) 106-12 (2009).

3. Simkova, V., Radermacher, P., and Barth, E. Metabolic effects of phophodiesterase III inhibitors: Another reason to promote their use? Crit Care 11(3) (2007).

4. Maskin, C.S., Sinoway, L., Chadwick, B., et al. Sustained hemodynamic and clinical effects of a new cardiotonic agent, WIN 47203, in patients with severe congestive heart failure. Circ J 67 1065-70 (1983).

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