CAY10606

Cayman Chemical Item Number 13381

(CAS 1159576-98-3)

CAY10606 (CAS 1159576-98-3)

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Description

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM).1 It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.1

1 Karg, E., Luderer, S., Pergola, C., et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem 52 3474-3483 (2009).

Formal Name 2-​[(3-​chlorophenyl)methyl]-​5-​hydroxy-​1H-​benz[g]indole-​3-​carboxylic acid,​ ethyl ester
CAS Number 1159576-98-3
Molecular Formula C22H18ClNO3
Formula Weight 379.8
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1=CC2=C(NC(CC3=CC=CC(Cl)​=C3)​=C2C(OCC)​=O)​C4=C1C=CC=C4
InCHI Code
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​1S/C22H18ClNO3/c1-2-27-22(26)​20-17-12-19(25)​15-8-3-4-9-16(15)​21(17)​24-18(20)​11-13-6-5-7-14(23)​10-13/h3-10,12,24-25H,2,11H2,1H3
InCHI Key
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UNDGVXYIMIZWAS-UHFFFAOYSA-N

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CAY10606 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $49.00 $0.00
5 mg $221.00 $0.00
10 mg $392.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-23. Prices are subject to change without notice.

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