CAY10606

Cayman Chemical Item Number 13381

(CAS 1159576-98-3)

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Description

5-Lipoxygenase (5-LO) initiates the synthesis of leukotrienes (LTs) from arachidonic acid, primarily in certain leukocyte populations. CAY10606 is a potent, reversible inhibitor of 5-LO, both in cell-free assays (IC50 = 86 nM) and in intact neutrophils (IC50 = 230 nM).1 It prevents the production of LTs in whole blood, whether 5-LO is activated with the calcium ionophore A23187 (IC50 = 1.6 μM) or formyl peptide (fMLP) following priming with lipopolysaccharide (IC50 = 830 nM). In rats subjected to carrageenan-induced pleurisy, CAY10606 significantly reduces both LT biosynthesis and the inflammatory reaction.1

1. Karg, E., Luderer, S., Pergola, C., et al. Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase. J Med Chem 52 3474-3483 (2009).

Formal Name 2-​[(3-​chlorophenyl)methyl]-​5-​hydroxy-​1H-​benz[g]indole-​3-​carboxylic acid,​ ethyl ester
CAS Number 1159576-98-3
Molecular Formula C22H18ClNO3
Formula Weight 379.8
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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OC1=CC2=C(NC(CC3=CC=CC(Cl)​=C3)​=C2C(OCC)​=O)​C4=C1C=CC=C4
InCHI Code
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​1S/C22H18ClNO3/c1-2-27-22(26)​20-17-12-19(25)​15-8-3-4-9-16(15)​21(17)​24-18(20)​11-13-6-5-7-14(23)​10-13/h3-10,12,24-25H,2,11H2,1H3
InCHI Key
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UNDGVXYIMIZWAS-UHFFFAOYSA-N

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CAY10606 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $49.00 $0.00
5 mg $221.00 $0.00
10 mg $392.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-02. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA

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