Bicyclo Prostaglandin E1

Cayman Chemical Item Number 13530

Bicyclo PGE1

Bicyclo Prostaglandin E1

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Description

Bicyclo Prostaglandin E1 (bicyclo PGE1) is a stable, base-catalyzed transformation product of the PGE1 metabolite 13,14-dihydro-15-keto PGE1. 13,14-dihydro-15-keto PGE1 itself is a metabolite of PGE11,2 found in human plasma at a median level of 10 pg/ml.3 Due to the inherent instability of 13,14-dihydro-15-keto PGE1, it is advisable to quantify it as bicyclo PGE1 to estimate PGE1 biosynthesis or metabolism in vivo.

1 Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).

2 Peskar, B.A., Cawello, W., Rogatti, W., et al. On the metabolism of prostaglandin E1 administered intravenously to human volunteers. J Physiol Pharmacol 42 327-331 (1991).

3 Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

Synonyms
  • Bicyclo PGE1
Formal Name 11-​deoxy-​13,​14-​dihydro-​15-​keto-​11β,​16ξ-​cycloprostaglandin E1
Molecular Formula C20H32O4
Formula Weight 336.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC1([H]​)​C(CC[C@H]​([C@H]​2CCCCCCC(O)​=O)​[C@@H]​1CC2=O)​=O
InCHI Code
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​1S/C20H32O4/c1-2-3-8-16-17-13-19(22)​15(14(17)​11-12-18(16)​21)​9-6-4-5-7-10-20(23)​24/h14-17H,2-13H2,1H3,(H,23,24)​/t14-,15-,16?,17+/m1/s1
InCHI Key
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SMKXBJMWSIFUAU-YKNYVSNTSA-N

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Bicyclo Prostaglandin E1 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $70.00 $0.00
5 mg $315.00 $0.00
10 mg $560.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-17. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

13,14-dihydro-15(R)-Prostaglandin E1
Prostaglandin E1

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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