tetranor-PGDM lactone • tetranor-<wbr/>Prostaglandin D Metabolite lactone (Inchi key KRZCZJUXOKTLEH-BZPMIXESSA-N) || Cayman Chemical | Supplier
tetranor-PGDM lactone
Item № 13564
Purity ≥90%
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25 µg $120.00 $0.00
50 µg $228.00 $0.00
100 µg $432.00 $0.00

Pricing updated 2015-09-02. Prices are subject to change without notice.

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  • tetranor-Prostaglandin D Metabolite lactone

Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.1 tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in human and mouse and, as such, is used as a biomarker of PGD2 biosynthesis.2 tetranor-PGDM lactone is a closed form of tetranor-PGDM. The formation of tetranor-PGDM lactone in biological samples has not been evaluated.

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Technical Information
Formal Name 8-​((4aR,​5R,​7aS)-​2,​6-​dioxooctahydrocyclopenta[b]pyran-​5-​yl)-​6-​oxooctanoic acid
  • tetranor-Prostaglandin D Metabolite lactone
Molecular Formula C16H22O6
Formula Weight 310.3
Purity ≥90%
Formulation A solution in methyl acetate
SMILES O=C(CCCCC(O)​=O)​CC[C@H]​1C(C[C@H]​2[C@@H]​1CCC(O2)​=O)​=O
InChI Code ​1S/C16H22O6/c17-10(3-1-2-4-15(19)​20)​5-6-11-12-7-8-16(21)​22-14(12)​9-13(11)​18/h11-12,14H,1-9H2,(H,19,20)​/t11-,12-,14+/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
Stability 6 months
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Download Product Insert 107 Kb PDF

Download Safety Data Sheet (SDS) 30 Kb PDF

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References & Background Reading
Product Description References

1. Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35 277-300 (1988).

2. Song, W., Wang, M., Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. J Biol Chem 283(2) 1179-1188 (2008).

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