tetranor-PGDM lactone

Cayman Chemical Item Number 13564

tetranor-Prostaglandin D Metabolite lactone

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Description

Prostaglandin D2 (PGD2) plays a pharmacological role in allergic and asthmatic anaphylaxis, normal physiological sleep and lowering of body temperature, as well as inhibits platelet aggregation and relaxes vascular smooth muscle.1 tetranor-PGDM is an abundant urinary metabolite of PGD2 that is detectable both in human and mouse and, as such, is used as a biomarker of PGD2 biosynthesis.2 tetranor-PGDM lactone is a closed form of tetranor-PGDM. The formation of tetranor-PGDM lactone in biological samples has not been evaluated.

1. Giles, H., and Leff, P. The biology and pharmacology of PGD2. Prostaglandins 35 277-300 (1988).

2. Song, W., Wang, M., Ricciotti, E., et al. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. J Biol Chem 283(2) 1179-1188 (2008).

Synonyms
  • tetranor-Prostaglandin D Metabolite lactone
Formal Name 8-​((4aR,​5R,​7aS)-​2,​6-​dioxooctahydrocyclopenta[b]pyran-​5-​yl)-​6-​oxooctanoic acid
Molecular Formula C16H22O6
Formula Weight 310.3
Formulation A solution in methyl acetate
Purity ≥90%
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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O=C(CCCCC(O)​=O)​CC[C@H]​1C(C[C@H]​2[C@@H]​1CCC(O2)​=O)​=O
InCHI Code
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​1S/C16H22O6/c17-10(3-1-2-4-15(19)​20)​5-6-11-12-7-8-16(21)​22-14(12)​9-13(11)​18/h11-12,14H,1-9H2,(H,19,20)​/t11-,12-,14+/m1/s1
InCHI Key
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KRZCZJUXOKTLEH-BZPMIXESSA-N

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Size Price Quantity Subtotal
25 µg $120.00 $0.00
50 µg $228.00 $0.00
100 µg $432.00 $0.00
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Pricing updated 2015-05-27. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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