13,14-dihydro-15-keto Prostaglandin E1

Cayman Chemical Item Number 13650

13,14-dihydro-15-keto PGE1 (CAS 5094-14-4)

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Description

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.1,2,3 Steady state plasma concentrations are about 10 pg/ml.1 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 µM, respectively, compared to PGE1 which has an IC50 of 40 nM.4

1. Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

2. Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).

3. Peskar, B.A., Cawello, W., Rogatti, W., et al. On the metabolism of prostaglandin E1 administered intravenously to human volunteers. J Physiol Pharmacol 42 327-331 (1991).

4. Kobzar, G., Mardla, V., Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proc Est Acad Sci Chem 40 179-180 (1991).

Synonyms
  • 13,14-dihydro-15-keto PGE1
Formal Name 9,​15-​dioxo-​11α-​hydroxy-​prostan-​1-​oic acid
CAS Number 5094-14-4
Molecular Formula C20H34O5
Formula Weight 354.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@H]​1[C@H]​(CCC(CCCCC)​=O)​[C@@H]​(CCCCCCC(OC)​=O)​C(C1)​=O
InCHI Code
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​1S/C21H36O5/c1-3-4-7-10-16(22)​13-14-18-17(19(23)​15-20(18)​24)​11-8-5-6-9-12-21(25)​26-2/h17-18,20,24H,3-15H2,1-2H3/t17-,18-,20-/m1/s1
InCHI Key
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GLJUFUWUOYSGMU-QWFCFKBJSA-N

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13,14-dihydro-15-keto Prostaglandin E1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
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