13,14-dihydro-15-keto Prostaglandin E1

Cayman Chemical Item Number 13650

13,14-dihydro-15-keto PGE1 (CAS 5094-14-4)

13,14-dihydro-15-keto Prostaglandin E1 (CAS 5094-14-4)

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Description

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.1,2,3 Steady state plasma concentrations are about 10 pg/ml.1 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 µM, respectively, compared to PGE1 which has an IC50 of 40 nM.4

1 Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

2 Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).

3 Peskar, B.A., Cawello, W., Rogatti, W., et al. On the metabolism of prostaglandin E1 administered intravenously to human volunteers. J Physiol Pharmacol 42 327-331 (1991).

4 Kobzar, G., Mardla, V., Järving, I., et al. Antiaggregating potency of E-type prostaglandins in human and rabbit platelets. Proc Est Acad Sci Chem 40 179-180 (1991).

Synonyms
  • 13,14-dihydro-15-keto PGE1
Formal Name 9,​15-​dioxo-​11α-​hydroxy-​prostan-​1-​oic acid
CAS Number 5094-14-4
Molecular Formula C20H34O5
Formula Weight 354.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCCC(=O)​CC[C@H]​1C(O)​CC(=O)​C1CCCCCCC(=O)​O
InCHI Code
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​1S/C20H34O5/c1-2-3-6-9-15(21)​12-13-17-16(18(22)​14-19(17)​23)​10-7-4-5-8-11-20(24)​25/h16-17,19,23H,2-14H2,1H3,(H,24,25)​/t16-,17-,19-/m1/s1
InCHI Key
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CDUVSQMTLOYKTR-ZHALLVOQSA-N

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13,14-dihydro-15-keto Prostaglandin E1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-16. Prices are subject to change without notice.

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