CAY10622

Cayman Chemical Item Number 13687

(CAS 1038549-25-5)

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Description

Two Rho kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.1,2,3 CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively.4 It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases.4

1. Olson, M.F. Applications for ROCK kinase inhibition. Curr Opin Cell Biol 20 242-248 (2008).

2. Narumiya, S., Tanji, M., and Ishizaki, T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev 28 65-76 (2009).

3. Watanabe, K., Ueno, M., Kamiya, D., et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotech 25(6) 681-686 (2007).

4. Morwick, T., Büttner, F.H., Cywin, C.L., et al. Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. J Med Chem 53 759-777 (2010).

Formal Name 3-​[[[[[4-​(aminocarbonyl)phenyl]amino]carbonyl]amino]methyl]-​N-​(1,​2,​3,​4-​tetrahydro-​7-​isoquinolinyl)-​benzamide
CAS Number 1038549-25-5
Molecular Formula C25H25N5O3
Formula Weight 443.5
Formulation A crystalline solid
Purity ≥98%
λmax 272 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC(C1=CC=C(NC(NCC2=CC(C(NC3=CC(CNCC4)​=C4C=C3)​=O)​=CC=C2)​=O)​C=C1)​=O
InCHI Code
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​1S/C25H25N5O3/c26-23(31)​18-5-7-21(8-6-18)​30-25(33)​28-14-16-2-1-3-19(12-16)​24(32)​29-22-9-4-17-10-11-27-15-20(17)​13-22/h1-9,12-13,27H,10-11,14-15H2,(H2,26,31)​(H,29,32)​(H2,28,30,33)​
InCHI Key
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SCIFUGGHOXNSJC-UHFFFAOYSA-N

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Size Price Quantity Subtotal
1 mg $49.00 $0.00
5 mg $221.00 $0.00
10 mg $392.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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