CAY10622 Exclusive

Cayman Chemical Item Number 13687

(CAS 1038549-25-5)

CAY10622 (CAS 1038549-25-5)

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Description

Two Rho kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.1,2,3 CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively.4 It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases.4

1 Olson, M.F. Applications for ROCK kinase inhibition. Curr Opin Cell Biol 20 242-248 (2008).

2 Narumiya, S., Tanji, M., and Ishizaki, T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev 28 65-76 (2009).

3 Watanabe, K., Ueno, M., Kamiya, D., et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotech 25(6) 681-686 (2007).

4 Morwick, T., Büttner, F.H., Cywin, C.L., et al. Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. J Med Chem 53 759-777 (2010).

Formal Name 3-​[[[[[4-​(aminocarbonyl)phenyl]amino]carbonyl]amino]methyl]-​N-​(1,​2,​3,​4-​tetrahydro-​7-​isoquinolinyl)-​benzamide
CAS Number 1038549-25-5
Molecular Formula C25H25N5O3
Formula Weight 443.5
Formulation A crystalline solid
Purity ≥98%
λmax 272 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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NC(C1=CC=C(NC(NCC2=CC(C(NC3=CC(CNCC4)​=C4C=C3)​=O)​=CC=C2)​=O)​C=C1)​=O
InCHI Code
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​1S/C25H25N5O3/c26-23(31)​18-5-7-21(8-6-18)​30-25(33)​28-14-16-2-1-3-19(12-16)​24(32)​29-22-9-4-17-10-11-27-15-20(17)​13-22/h1-9,12-13,27H,10-11,14-15H2,(H2,26,31)​(H,29,32)​(H2,28,30,33)​
InCHI Key
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SCIFUGGHOXNSJC-UHFFFAOYSA-N

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CAY10622 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $46.00 $0.00
5 mg $207.00 $0.00
10 mg $368.00 $0.00
25 mg $805.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-20. Prices are subject to change without notice.

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