Item № 13687
CAS № 1038549-25-5
Purity ≥98%
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1 mg $49.00 $0.00
5 mg $221.00 $0.00
10 mg $392.00 $0.00

Pricing updated 2015-10-06. Prices are subject to change without notice.

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Two Rho kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The Rho kinases play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal.1,2,3 CAY10622 is a potent, ureidobenzamide inhibitor of ROCK-I and ROCK-II kinases with IC50 values of 6 and 4 nM, respectively.4 It is inactive (showing greater then 100-fold selectivity) against an additional 44 kinases.4

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Technical Information
Formal Name 3-[[[[[4-(aminocarbonyl)phenyl]amino]carbonyl]amino]methyl]-N-(1,2,3,4-tetrahydro-7-isoquinolinyl)-benzamide
CAS Number 1038549-25-5
Molecular Formula C25H25N5O3
Formula Weight 443.5
Purity ≥98%
Formulation A crystalline solid
λmax 272 nm
InChI Code 1S/C25H25N5O3/c26-23(31)18-5-7-21(8-6-18)30-25(33)28-14-16-2-1-3-19(12-16)24(32)29-22-9-4-17-10-11-27-15-20(17)13-22/h1-9,12-13,27H,10-11,14-15H2,(H2,26,31)(H,29,32)(H2,28,30,33)

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Olson, M.F. Applications for ROCK kinase inhibition. Curr Opin Cell Biol 20 242-248 (2008).

2. Narumiya, S., Tanji, M., and Ishizaki, T. Rho signaling, ROCK and mDia1, in transformation, metastasis and invasion. Cancer Metastasis Rev 28 65-76 (2009).

3. Watanabe, K., Ueno, M., Kamiya, D., et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotech 25(6) 681-686 (2007).

4. Morwick, T., Büttner, F.H., Cywin, C.L., et al. Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. J Med Chem 53 759-777 (2010).

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