15(R)-Prostaglandin E1

Cayman Chemical Item Number 13710

15(R)-PGE1; 15-epi PGE1 (CAS 20897-91-0)

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Description

15(R)-PGE1 is the “unnatural” C-15 stereoisomer of PGE1. It is essentially inactive biologically when compared to PGE1.1 It is a non-competitive inhibitor of 15-hydroxy PGDH with an IC50 of 189 µM.2

1. Nakano, J. Relationship between the chemical structure of prostaglandins and their vasoactivities in dogs. Br J Pharmacol 44 63-70 (1972).

2. Jarabak, J., and Braithwaite, S.S. Kinetic studies on a 15-hydroxyprostaglandin dehydrogenase from human placenta. The reaction mechanism and the mechanism of action of various inhibitors.. Arch Biochem Biophys 177 245-254 (1976).

Synonyms
  • 15(R)-PGE1
  • 15-epi PGE1
Formal Name 9-​oxo-​11α,​15R-​dihydroxy-​prost-​13E-​en-​1-​oic acid
CAS Number 20897-91-0
Molecular Formula C20H34O5
Formula Weight 354.5
Formulation A solution in methyl acetate
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@@H]​(O)​/C=C/[C@H]​1C(O)​CC(=O)​C1CCCCCCC(=O)​O
InCHI Code
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​1S/C20H34O5/c1-2-3-6-9-15(21)​12-13-17-16(18(22)​14-19(17)​23)​10-7-4-5-8-11-20(24)​25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)​/b13-12+/t15-,16-,17-,19-/m1/s1
InCHI Key
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GMVPRGQOIOIIMI-CHCORRSHSA-N

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15(R)-Prostaglandin E1 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
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Pricing updated 2015-03-30. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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