Butaprost (free acid)
Item № 13741
CAS № 433219-55-7
Purity ≥95%
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500 µg $85.00 $0.00
1 mg $162.00 $0.00
5 mg $680.00 $0.00
10 mg $1,190.00 $0.00

Pricing updated 2015-11-28. Prices are subject to change without notice.

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  • (±)-15-deoxy-16S-hydroxy-17-cyclobutyl PGE1
  • 15-deoxy-16S-hydroxy-17-cyclobutyl PGE1

Butaprost is an EP2 selective agonist which has frequently been used to pharmacologically define the EP receptor expression profile of various human and animal tissues and cells.1,2 Prostaglandin free acids generally bind to their cognate receptors with 10 to 100 times the affinity of the corresponding ester derivative. Consistent with this trend, butaprost binds to membranes from EP2 receptor-transfected CHO cells with a Ki value of 2,400 nM, whereas butaprost (free acid) and CAY10399 (the 2-series congener of butaprost free acid) exhibit significantly lower Ki values of 73 and 92 nM, respectively.3 Butaprost (free acid) is therefore another useful tool for characterizing EP receptor-mediated signalling events.

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Technical Information
Formal Name 9-oxo-11α,16S-dihydroxy-17-cyclobutyl-prost-13E-en-1-oic acid
CAS Number 433219-55-7
  • (±)-15-deoxy-16S-hydroxy-17-cyclobutyl PGE1
  • 15-deoxy-16S-hydroxy-17-cyclobutyl PGE1
Molecular Formula C23H38O5
Formula Weight 394.6
Purity ≥95%
Formulation A solution in methyl acetate
InChI Code 1S/C23H38O5/c1-2-13-23(14-8-15-23)21(26)11-7-10-18-17(19(24)16-20(18)25)9-5-3-4-6-12-22(27)28/h7,10,17-18,20-21,25-26H,2-6,8-9,11-16H2,1H3,(H,27,28)/b10-7+/t17-,18-,20-,21+/m1/s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 2 years
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Download Safety Data Sheet (SDS) 31 Kb PDF

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References & Background Reading
Product Description References

1. Kiriyama, M., Ushikubi, F., Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol 122 217-224 (1997).

2. Lawrence, R.A., and Jones, R.L. Investigation of the prostaglandin E (EP-) receptor subtype mediating relaxation of the rabbit jugular vein. Br J Pharmacol 105 817-824 (1992).

3. Tani, K., Naganawa, A., Ishida, A., et al. Design and synthesis of a highly selective EP2-receptor agonist. Bioorg Med Chem Lett 11 2025-2028 (2001).

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