Limaprost • 17α,20-<wbr/>dimethyl-<wbr/>Δ<sup>2</sup>-<wbr/>PGE<sub>1</sub>; 17α,20-<wbr/>dimethyl-<wbr/>Δ<sup>2</sup>-<wbr/>Prostaglandin E<sub>1</sub> (CAS 74397-12-9) (Inchi key OJZYRQPMEIEQFC-UAWLTFRCSA-N) || Cayman Chemical | Supplier
Limaprost
Item № 13810
CAS № 74397-12-9
Purity >98%
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SIZE PRICE QUANTITY SUBTOTAL
CART TOTAL $0.00
1 mg $57.00 $0.00
5 mg $257.00 $0.00
10 mg $456.00 $0.00
50 mg $1,995.00 $0.00

Pricing updated 2015-09-01. Prices are subject to change without notice.

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Description
Synonyms
  • 17α,20-dimethyl-Δ2-PGE1
  • 17α,20-dimethyl-Δ2-Prostaglandin E1

Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.1

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Technical Information
Formal Name 11α,​15S-​dihydroxy-​17S,​20-​dimethyl-​9-​oxo-​prosta-​2E,​13E-​dien-​1-​oic acid
CAS Number 74397-12-9
Synonyms
  • 17α,20-dimethyl-Δ2-PGE1
  • 17α,20-dimethyl-Δ2-Prostaglandin E1
Molecular Formula C22H36O5
Formula Weight 380.5
Purity >98%
Formulation A crystalline solid
SMILES O[C@H]​1[C@H]​(/C=C/[C@@H]​(O)​C[C@@H]​(C)​CCCC)​[C@@H]​(CCCC/C=C/C(O)​=O)​C(C1)​=O
InChI Code ​1S/C22H36O5/c1-3-4-9-16(2)​14-17(23)​12-13-19-18(20(24)​15-21(19)​25)​10-7-5-6-8-11-22(26)​27/h8,11-13,16-19,21,23,25H,3-7,9-10,14-15H2,1-2H3,(H,26,27)​/b11-8+,13-12+/t16-,17+,18+,19+,21+/m0/s1
InChI Key OJZYRQPMEIEQFC-UAWLTFRCSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 79 Kb PDF

Download Safety Data Sheet (SDS) 29 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn 247 89-102 (1980).

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