Limaprost

Cayman Chemical Item Number 13810

17α,20-dimethyl-Δ2-PGE1; 17α,20-dimethyl-Δ2-Prostaglandin E1 (CAS 74397-12-9)

Limaprost (CAS 74397-12-9)

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Description

Limaprost is an analog of PGE1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is orally active in both rats and guinea pigs at doses of 100 µg/kg as an inhibitor of ADP and collagen induced platelet aggregation. Limaprost is 10-1,000 times more potent than PGE1 as an inhibitor of platelet adhesiveness measured in vitro. Intra-coronary injection (100 ng/kg) or intravenous injection (3 µg/kg) in anesthetized dogs causes vasodilation and increased coronary blood flow by 60-80%. Significant hypotensive effects were seen at 100 and 300 µg/kg orally in rats.1

1 Tsuboi, T., Hatano, N., Nakatsuji, K., et al. Pharmacological evaluation of OP 1206, a prostaglandin E1 derivative, as an antianginal agent. Arch Int Pharmacodyn 247 89-102 (1980).

Synonyms
  • 17α,20-dimethyl-Δ2-PGE1
  • 17α,20-dimethyl-Δ2-Prostaglandin E1
Formal Name 11α,​15S-​dihydroxy-​17S,​20-​dimethyl-​9-​oxo-​prosta-​2E,​13E-​dien-​1-​oic acid
CAS Number 74397-12-9
Molecular Formula C22H36O5
Formula Weight 380.5
Formulation A crystalline solid
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@H]​1[C@H]​(/C=C/[C@@H]​(O)​C[C@@H]​(C)​CCCC)​[C@@H]​(CCCC/C=C/C(O)​=O)​C(C1)​=O
InCHI Code
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​1S/C22H36O5/c1-3-4-9-16(2)​14-17(23)​12-13-19-18(20(24)​15-21(19)​25)​10-7-5-6-8-11-22(26)​27/h8,11-13,16-19,21,23,25H,3-7,9-10,14-15H2,1-2H3,(H,26,27)​/b11-8+,13-12+/t16-,17+,18+,19+,21+/m0/s1
InCHI Key
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OJZYRQPMEIEQFC-UAWLTFRCSA-N

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Limaprost is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $57.00 $0.00
5 mg $257.00 $0.00
10 mg $456.00 $0.00
50 mg $1,995.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-25. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

3-methoxy Limaprost
Prostaglandin E1

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