DOI (hydrochloride)

Cayman Chemical Item Number 13885

2,5-dimethoxy-4-Iodoamphetamine (CAS 42203-78-1)

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2,5-dimethoxy-4-iodoamphetamine (DOI) is a hallucinogenic designer drug that is commonly found on the illicit drug market.1 It potently binds and activates the human serotonin 5-HT2 receptors (Ki = 0.7, 20, and 2.4 nM for 5-HT2A, 5-HT2B, and 5-HT2C, respectively).2,3 Methods for detecting DOI in human urine have been published.4 This product is intended for forensic and research purposes.

1. Bruno, R., Matthews, A.J., Dunn, M., et al. Emerging psychoactive substance use among regular ecstasy users in Australia. Drug Alcohol Depend 124(1-2) 19-25 (2012).

2. Nelson, D.L., Lucaites, V.L., Wainscott, D.B., et al. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol 359(1) 1-6 (1999).

3. Braden, M.R., Parrish, J.C., Naylor, J.C., et al. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Mol Pharm 70(6) 1956-1965 (2006).

4. Kerrigan, S., Banuelos, S., Perrella, L., et al. Simultaneous detection of ten psychedelic phenethylamines in urine by gas chromatography-mass spectrometry. J Anal Toxicol 35(7) 459-469 (2011).

  • 2,5-dimethoxy-4-Iodoamphetamine
Formal Name 4-​iodo-​2,​5-​dimethoxy-​a-​methyl-​benzeneethanamine,​ monohydrochloride
CAS Number 42203-78-1
Molecular Formula C11H16INO2 • HCl
Formula Weight 357.6
Formulation A crystalline solid
Purity ≥98%
λmax 235, 300 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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Size Price Quantity Subtotal
5 mg $49.00 $0.00
10 mg $88.00 $0.00
50 mg $392.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-27. Prices are subject to change without notice.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

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