2,5-dimethoxy-4-iodoamphetamine (DOI) is a hallucinogenic designer drug that is commonly found on the illicit drug market.1 It potently binds and activates the human serotonin 5-HT2 receptors (Ki = 0.7, 20, and 2.4 nM for 5-HT2A, 5-HT2B, and 5-HT2C, respectively).2,3 Methods for detecting DOI in human urine have been published.4 This product is intended for forensic and research purposes.
1Bruno, R., Matthews, A.J., Dunn, M., et al. Emerging psychoactive substance use among regular ecstasy users in Australia. Drug Alcohol Depend124(1-2)19-25(2012).
2Nelson, D.L., Lucaites, V.L., Wainscott, D.B., et al. Comparisons of hallucinogenic phenylisopropylamine binding affinities at cloned human 5-HT2A, 5-HT2B and 5-HT2C receptors. Naunyn Schmiedebergs Arch Pharmacol359(1)1-6(1999).
3Braden, M.R., Parrish, J.C., Naylor, J.C., et al. Molecular interaction of serotonin 5-HT2A receptor residues Phe339(6.51) and Phe340(6.52) with superpotent N-benzyl phenethylamine agonists. Mol Pharm70(6)1956-1965(2006).
4Kerrigan, S., Banuelos, S., Perrella, L., et al. Simultaneous detection of ten psychedelic phenethylamines in urine by gas chromatography-mass spectrometry. J Anal Toxicol35(7)459-469(2011).
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.
Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.
Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research
Analytical testing services and custom synthesis also available