Prostaglandin E2 methyl ester Exclusive

Cayman Chemical Item Number 14011

PGE2 methyl ester; Dinoprostone methyl ester (CAS 31753-17-0)

Prostaglandin E2 methyl ester (CAS 31753-17-0)

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Description

PGE2 methyl ester is an analog of PGE2 with enhanced lipid solubility. Prostaglandin esters are generally hydrolyzed to the free acid upon in vivo administration, making the methyl esters useful prodrugs.1 In general, methyl esters show greatly decreased agonist activity in vitro compared to the free acids.

1 Miller, W.L., and Sutton, M.J. Relative biological activity of certain prostaglandins and their enantiomers. Prostaglandins 11 77-84 (1976).

Synonyms
  • PGE2 methyl ester
  • Dinoprostone methyl ester
Formal Name 9-​oxo-​11α,​15S-​dihydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ methyl ester
CAS Number 31753-17-0
Molecular Formula C21H34O5
Formula Weight 366.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O=C1[C@H]​(C/C=C\CCCC(OC)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@H]​(O)​C1
InCHI Code
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​1S/C21H34O5/c1-3-4-7-10-16(22)​13-14-18-17(19(23)​15-20(18)​24)​11-8-5-6-9-12-21(25)​26-2/h5,8,13-14,16-18,20,22,24H,3-4,6-7,9-12,15H2,1-2H3/b8-5-,14-13+/t16-,17+,18+,20+/m0/s1
InCHI Key
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WGCXTGBZBFBQPP-ZYONDNFOSA-N

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Prostaglandin E2 methyl ester is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $25.00 $0.00
1 mg $48.00 $0.00
5 mg $200.00 $0.00
10 mg $350.00 $0.00
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Pricing updated 2014-04-23. Prices are subject to change without notice.

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Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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