Cayman is a manufacturer, supplier, and vendor of biochemical reagents,
assay kits, forensic chemistry standards, antibodies, and proteins for
scientific research. Analytical testing services and custom synthesis are
Cayman Chemical Company
· 1180 East Ellsworth Road
· Ann Arbor, Michigan 48108
AH 6809 is an EP and DP receptor antagonist with nearly equal affinity for the cloned human EP1, EP2, EP3-III, and DP1 receptors.1 AH 6809 blocks the PGE2-induced accumulation of cAMP in COS cells transfected with the human EP2 receptor.2 It also blocks the accumulation of Ca2+ in Xenopus oocytes expressing the human EP1 receptor.3 In the human and guinea pig, the activity profile of AH 6809 is similar to that of SC-19220, but it is somewhat more potent.4 In the mouse, AH 6809 has the highest affinity for the EP2 receptor, but also acts as a weak ligand at the murine EP1 and DP1 receptors.5 In whole human platelets, AH 6809 is an effective antagonist of the antiaggregatory actions of PGD2, but not PGI2, with an EC50 of about 5 x 10−5 M.6
1.Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta1483285-293(2000).
2.Woodward, D.F., Pepperl, D.J., Burkey, T.H., et al. 6-Isopropoxy-9-oxoxanthene-2-carboxylic acid (AH 6809), a human EP2 receptor antagonist. Biochem Pharmacol501731-1733(1995).
3.Funk, C.D., Furci, L., Fitzgerald, G.A., et al. Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. J Biol Chem26826767-26772(1993).
4.Coleman, R.A., Kennedy, I., and Sheldrick, R.L.G.AH6809, a prostanoid EP1 receptor blocking drug. Br J Pharmacol85273P(1985).
5.Kiriyama, M., Ushikubi, F., Kobayashi, T., et al. Ligand binding specificities of the eight types and subtypes of the mouse prostanoid receptors expressed in Chinese hamster ovary cells. Br J Pharmacol122217-224(1997).
6.Keery, R.J., and Lumley, P.AH6809, a prostaglandin DP-receptor blocking drug on human platelets. Br J Pharmacol94745-754(1988).
A crystalline solid
244, 305 nm
in continental US; may vary elsewhere
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.
Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.