9-deoxy-9-methylene Prostaglandin E2

Cayman Chemical Item Number 14410

9-deoxy-9-methylene PGE2 (CAS 61263-32-9)

9-deoxy-9-methylene Prostaglandin E2 (CAS 61263-32-9)

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Description

9-deoxy-9-methylene PGE2 is a stable, isosteric analog of PGE2. 9-deoxy-9-methylene PGE2 retains the biological profile of PGE2 with fewer side effects. In the rat 9-deoxy-9-methylene PGE2 is equipotent to PGE2 in decreasing blood pressure. It also stimulates the gerbil colon and primate uterus at the same potency as PGE2.1

1 Bundy, G.L., Kimball, F.A., Robert, A., et al. Synthesis and biological activity of 9-deoxo-9-methylene and related prostaglandins. Adv Prostaglandin Thromboxane Res 6 355-363 (1980).

Synonyms
  • 9-deoxy-9-methylene PGE2
Formal Name 9-​methylene-​11α,​15S-​dihydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 61263-32-9
Molecular Formula C21H34O4
Formula Weight 350.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@H]​1[C@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@@H]​(C/C=C\CCCC(O)​=O)​C(C1)​=C
InCHI Code
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​1S/C21H34O4/c1-3-4-7-10-17(22)​13-14-19-18(16(2)​15-20(19)​23)​11-8-5-6-9-12-21(24)​25/h5,8,13-14,17-20,22-23H,2-4,6-7,9-12,15H2,1H3,(H,24,25)​/b8-5-,14-13+/t17-,18-,19+,20+/m0/s1
InCHI Key
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VKEJXDXJUFQESA-DLMPNJEASA-N

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9-deoxy-9-methylene Prostaglandin E2 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $59.00 $0.00
5 mg $266.00 $0.00
10 mg $472.00 $0.00
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Pricing updated 2014-04-24. Prices are subject to change without notice.

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