9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2
Item № 14420
CAS № 61263-35-2
Purity >98%
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500 µg $37.00 $0.00
1 mg $70.00 $0.00
5 mg $296.00 $0.00
10 mg $518.00 $0.00

Pricing updated 2015-09-05. Prices are subject to change without notice.

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Description
Synonyms
  • 9-deoxy-9-methylene-16,16-dimethyl PGE2
  • Meteneprost

9-deoxy-9-methylene-16,16-dimethyl Prostaglandin E2 (Meteneprost) is a potent analog of prostaglandin E2 (PGE2; Item No. 14010) with an extended half-life in vivo. In combination with various other prostaglandin derivatives, it results in the termination of first trimester pregnancy in monkeys. A single intramuscular injection containing 0.5 mg of meteneprost and 7.5 mg of 17-phenyl trinor PGF is very effective in terminating early pregnancy.1 This prostaglandin mixture is ineffective on monkeys in their third trimester of pregnancy.1 Meteneprost, when compared to PGE2 and PGF, in monkey and rat, does not result in unwanted side effects such as fever or gastrointestinal problems.1,2

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Technical Information
Formal Name 9-​methylene-​11α,​15R-​dihydroxy-​16,​16-​dimethyl-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 61263-35-2
Synonyms
  • 9-deoxy-9-methylene-16,16-dimethyl PGE2
  • Meteneprost
Molecular Formula C23H38O4
Formula Weight 378.6
Purity >98%
Formulation A solution in methyl acetate
SMILES CCCCC(C)​(C)​[C@H]​(O)​/C=C/[C@@H]​1[C@@H]​(C/C=C\CCCC(O)​=O)​C(C[C@H]​1O)​=C
InChI Code ​1S/C23H38O4/c1-5-6-15-23(3,4)​21(25)​14-13-19-18(17(2)​16-20(19)​24)​11-9-7-8-10-12-22(26)​27/h7,9,13-14,18-21,24-25H,2,5-6,8,10-12,15-16H2,1,3-4H3,(H,26,27)​/b9-7-,14-13+/t18-,19+,20+,21+/m0/s1
InChI Key WMLGLMGSFIXSGO-KTXJXPLISA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 166 Kb PDF

Download Safety Data Sheet (SDS) 30 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Wilks, J.W. Pregnancy interception with a combination of prostaglandins: Studies in monkeys. Science 221 1407-1409 (1983).

2. Bundy, G.L., Kimball, F.A., Robert, A., et al. Synthesis and biological activity of 9-deoxo-9-methylene and related prostaglandins. Adv Prostaglandin Thromboxane Res 6 355-363 (1980).

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