Bicyclo Prostaglandin E2

Cayman Chemical Item Number 14530

Bicyclo PGE2 (CAS 74158-09-1)

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Bicyclo prostaglandin E2 (bicyclo PGE2) is a stable breakdown product of PGE2 and 13,14-dihydro-15-keto PGE2. Bicyclo PGE2 is a stable, base-catalyzed transformation product of 13,14-dihydro-15-keto PGE2. 13,14-dihydro-15-keto PGE2 itself is a metabolite of PGE21 found in human plasma at a median level of 20-25 pg/ml.2 Due to the inherent instability of 13,14-dihydro-15-keto PGE2, it is advisable to quantify it as bicyclo PGE2 to estimate PGE2 biosynthesis or metabolism in vivo.3,4

1. Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).

2. Leonhardt, A., Krauss, M., Gieler, U., et al. In vivo formation of prostaglandin E1 and prostaglandin E2 in atopic dermatitis. Br J Dermatol 136 337-340 (1997).

3. Murphy, R.C., and Fitzgerald, G.A. Current approaches to estimation of eicosanoid formation in vivo. Adv Prostaglandin Thromboxane Leukot Res 22 341-348 (1994).

4. Granström, E., Hamberg, M., Hansson, G., et al. Chemical instability of 15-keto-13,14-dihydro-PGE2: The reason for low assay reliability. Prostaglandins 19 933-945 (1980).

  • Bicyclo PGE2
Formal Name 11-​deoxy-​13,​14-​dihydro-​15-​keto-​11β,​16.xi.-​cycloprostaglandin E2
CAS Number 74158-09-1
Molecular Formula C20H30O4
Formula Weight 334.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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Bicyclo Prostaglandin E2 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $59.00 $0.00
5 mg $266.00 $0.00
10 mg $472.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-02. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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13,14-dihydro-15-keto Prostaglandin E2


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Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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