15-keto Prostaglandin E2

Cayman Chemical Item Number 14720

15-keto PGE2 (CAS 26441-05-4)

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15-keto Prostaglandin E2 (15-keto PGE2) is a metabolite of PGE2 formed by 15-hydroxy PGDH.1,2 In vivo, 15-keto PGE2 is essentially inactive. It has an attenuated affinity for the EP4 and EP2 receptors compared to PGE2 (Ki = 2,600-15,000 nM for the inhibition of PGE2 binding compared to a Kd = 1 nM for PGE2).3

1. Hamberg, M., and Samuelsson, B. On the metabolism of prostaglandins E1 and E2 in man. J Biol Chem 246 6713-6721 (1971).

2. Mak, O.T., Liu, Y., and Tai, H. Purification and characterization of NAD+-dependent 15-hydroxyprostaglandin dehydrogenase from porcine kidney. Biochim Biophys Acta 1035 190-196 (1990).

3. Nishigaki, N., Negishi, M., and Ichikawa, A. Two Gs-coupled prostaglandin E receptor subtypes, EP2 and EP4, differ in desensitization and sensitivity to the metabolic inactivation of the agonist. Mol Pharmacol 50 1031-1037 (1996).

  • 15-keto PGE2
Formal Name 9,​15-​dioxo-​11α-​hydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 26441-05-4
Molecular Formula C20H30O5
Formula Weight 350.5
Formulation A crystalline solid
Purity ≥99%
λmax 229 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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15-keto Prostaglandin E2 is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $52.00 $0.00
1 mg $99.00 $0.00
5 mg $416.00 $0.00
10 mg $728.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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