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Cayman is a manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research. Analytical testing services and custom synthesis are also available.

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

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15(R)-15-methyl Prostaglandin E2

Cayman Chemical Item Number 14725

Arbaprostil; 15(R)-15-methyl PGE2 (CAS 55028-70-1)

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15(R)-15-methyl PGE2 is a prodrug for the potent PGE2 analog 15(S)-15-methyl PGE2.1 Acid-catalyzed epimerization in the stomach produces the 15(S)-hydroxy compound which is biologically active.2 Oral administration of 15(R)-15-methyl PGE2 to dogs or rats at 10-300 µg/kg results in a dose-dependent inhibition of gastric acid secretion and an increase in the rate of duodenal bicarbonate secretion.3,4

1. Yankee, E.W., Axen, U., and Bundy, G.L. Total synthesis of 15-methylprostaglandins. J Am Chem Soc 96 5865-5876 (1974).

2. Takanashi, H., Kawabe, Y., and Akima, M. Acid-promoted epimerization of arbaprostil, 15(R)-15-methylprostaglandin E2, elicits gastric antisecretory activities in rats. Jpn J Pharmacol 57 559-564 (1991).

3. Takanashi, H., and Itoh, Z. Gastric antisecretory activity of 15(R)-15-methylprostaglandin E2, arbaprostil, in dogs. Jpn J Pharmacol 57 447-451 (1991).

4. Li, J., Nagata, T., Yoshida, M., et al. Effect of 15(R)-15-methyl PGE2 (arbaprostil) on duodenal bicarbonate secretion in rat. Gastroenerol Jpn 24 8-11 (1989).

  • Arbaprostil
  • 15(R)-15-methyl PGE2
Formal Name 9-​oxo-​11α,​15R-​dihydroxy-​15-​methyl-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 55028-70-1
Molecular Formula C21H34O5
Formula Weight 366.5
Formulation A crystalline solid
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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15(R)-15-methyl Prostaglandin E2 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $59.00 $0.00
5 mg $266.00 $0.00
10 mg $472.00 $0.00
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Pricing updated 2015-02-27. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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