17-phenyl trinor Prostaglandin E2

Cayman Chemical Item Number 14810

17-phenyl trinor PGE2 (CAS 38315-43-4)

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Description

17-phenyl trinor PGE2 is a synthetic analog of PGE2. It is an EP1 and EP3 receptor agonist.1,2 17-phenyl trinor PGE2 causes contraction of the guinea pig ileum at a concentration of 11 µM.1 It is slightly less potent than PGE2 in stimulating gerbil colon and rat uterus.2 With an ED50 value of 350 µg/kg, 17-phenyl trinor PGE2 is 4.4 times more potent than PGE2 as an antifertility agent in hamsters.2

1. Lawrence, R.A., Jones, R.L., and Wilson, N.H. Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum. Br J Pharmacol 105 271-278 (1992).

2. Miller, W.L., Weeks, J.R., Lauderdale, J.W., et al. Biological activities of 17-phenyl-18,19,20-trinorprostaglandins. Prostaglandins 9 9-18 (1975).

Synonyms
  • 17-phenyl trinor PGE2
Formal Name 9-​oxo-​11α,​15S-​dihydroxy-​17-​phenyl-​18,​19,​20-​trinor-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 38315-43-4
Molecular Formula C23H30O5
Formula Weight 386.5
Formulation A crystalline solid
Purity >98%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@H]​1[C@H]​(/C=C/[C@@H]​(O)​CCC2=CC=CC=C2)​[C@@H]​(C/C=C\CCCC(O)​=O)​C(C1)​=O
InCHI Code
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​1S/C23H30O5/c24-18(13-12-17-8-4-3-5-9-17)​14-15-20-19(21(25)​16-22(20)​26)​10-6-1-2-7-11-23(27)​28/h1,3-6,8-9,14-15,18-20,22,24,26H,2,7,10-13,16H2,(H,27,28)​/b6-1-,15-14+/t18-,19+,20+,22+/m0/s1
InCHI Key
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FOBVMYJQWZOGGJ-XYRJXBATSA-N

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17-phenyl trinor Prostaglandin E2 is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $33.00 $0.00
1 mg $63.00 $0.00
5 mg $264.00 $0.00
10 mg $462.00 $0.00
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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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