2,3-dinor-6-keto Prostaglandin F (sodium salt)

Cayman Chemical Item Number 15120

2,3-dinor-6-keto PGF (sodium salt)

2,3-dinor-6-keto Prostaglandin F1α (sodium salt)

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Description

2,3-dinor-6-keto prostaglandin F (2,3-dinor-6-keto PGF) is the β-oxidation product of 6-keto PGF and the major urinary metabolite of PGI2 in humans.1,2 2,3-dinor-6-keto PGF makes up 23% of the recovered radioactivity in urine after administration of labeled 6-keto PGF and 20.5% after administration of labeled PGI2.2 In healthy human subjects, the average excreted 2,3-dinor-6-keto PGF level is ~100 pg/mg creatinine.3

1 Fitzgerald, G.A., Lawson, J., Blair, I.A., et al. Analysis of urinary metabolites of thromboxane and prostacyclin by negative-ion chemical-ionization gas chromatography/mass spectrometry. Adv Prostaglandin Thromboxane Leukot Res 15 87-90 (1985).

2 Rosenkranz, B., Fischer, C., Reimann, I., et al. Identification of the major metabolite of prostacyclin and 6-ketoprostaglandin F in man. Biochim Biophys Acta 619 207-213 (1980).

3 Wennmalm Å, Benthin, G., Granström, E.F., et al. 2,3-Dinor metabolites of thromboxane A2 and prostacyclin in urine from healthy human subjects: Diurnal variation and relation to 24h excretion. Clin Sci 83 461-465 (1992).

Synonyms
  • 2,3-dinor-6-keto PGF (sodium salt)
Formal Name 6-​oxo-​9α,​11α,​15S-​trihydroxy-​2,​3-​dinor-​prost-​13E-​en-​1-​oic acid,​ sodium salt
Molecular Formula C18H29O6 · Na
Formula Weight 364.4
Formulation A lyophilized powder
Purity ≥95%
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@H]​(CC(CCC([O-]​)​=O)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@H]​(O)​C1.[Na+]​
InCHI Code
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​1S/C18H30O6.Na/c1-2-3-4-5-12(19)​6-8-14-15(17(22)​11-16(14)​21)​10-13(20)​7-9-18(23)​24;/h6,8,12,14-17,19,21-22H,2-5,7,9-11H2,1H3,(H,23,24)​;/q;+1/p-1/b8-6+;/t12-,14+,15+,16+,17-;/m0./s1
InCHI Key
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CXELZMXZXOSIRU-DBAZFWCESA-M

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2,3-dinor-6-keto Prostaglandin F1α (sodium salt) is available in the following screening libraries:

Size Price Quantity Subtotal
100 µg $29.00 $0.00
500 µg $131.00 $0.00
1 mg $232.00 $0.00
5 mg $1,015.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-24. Prices are subject to change without notice.

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6-keto Prostaglandin F
Prostaglandin F

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