Cayman Chemical Item Number 15590

(pGlu1)Apelin-13; Pyr-Apelin-13; (Pyr1)Apelin-13 (CAS 217082-60-5)

See more


The apelin gene encodes a pre-proprotein that is processed to generate bioactive peptides consisting of 36, 17, or 13 amino acids: apelin-36 (Item No. 13524), apelin-17, and apelin-13 (Item No. 13523), respectively. Apelin-13 is an endogenous ligand of the APJ receptor, activating this G protein-coupled receptor with an EC50 value of 0.37 nM.1,2 (Glp1)-Apelin-13 is a pyroglutamylated form of apelin-13, in that the N-terminal glutamine residue is cyclized to pyroglutamic acid. Like apelin-13, this compound is a potent APJ receptor agonist (EC50 = 0.30 nM).1 (Glp1)-Apelin-13 is the major apelin isoform in the plasma of healthy human subjects.3 It can have vasoconstrictor and antipyretic effects in vitro and in vivo.4,5,6

1. Tatemoto, K., Hosoya, M., Habata, Y., et al. Isolation and characterizaton of a novel endogenous peptide ligand for the human APJ receptor. Biochem Biophys Res Commun 251 471-476 (1998).

2. Lee, D.K., Cheng, R., Nguyen, T., et al. Characterization of apelin, the ligand for the APJ receptor. J Neurochem 74 34-41 (2000).

3. Zhen, E.Y., Higgs, R.E., and Gutierrez, J.A. Pyroglutamyl apelin-13 identified as the major apelin isoform in human plasma. Anal Biochem 442(1) 1-9 (2013).

4. Katugampola, S.D., Maguire, J.J., Matthewson, S.R., et al. [125I]-(Pyr1)Apelin-13 is a novel radioligand for localizing the APJ orphan receptor in human and rat tissues with evidence for a vasoconstrictor role in man. Br J Pharmacol 132(6) 1255-1260 (2001).

5. Kagiyama, S., Fukuhara, M., Matsumura, K., et al. Central and peripheral cardiovascular actions of apelin in conscious rats. Regul Pept 125(1-3) 55-59 (2005).

6. Hatzelmann, T., Harden, L.M., Roth, J., et al. Antipyretic effect of central [Pyr1]apelin13 on LPS-induced fever in the rat. Regul Pept 184 6-13 (2013).

  • (pGlu1)Apelin-13
  • Pyr-Apelin-13
  • (Pyr1)Apelin-13
CAS Number 217082-60-5
Formula Weight 1533.8
Formulation A white to off-white solid
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Copy SMILES to clipboard
InCHI Code
Copy InCHI code to clipboard
Copy InCHI key to clipboard

Download free InCHI Key generation software

Size Price Quantity Subtotal
1 mg $109.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-07-28. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products



Batch-specific Information

Get batch-specific data and documents by batch number

Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


Please wait...