17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F

Cayman Chemical Item Number 15895

17-TFM-PGF (CAS 1027401-98-4)

See more


A number of 17-aryl trinor and 16-aryloxy tetranor prostaglandin F derivatives have been approved for the treatment of glaucoma.1,2,3 These “ring” prostaglandin (PG) analogs have improved efficacy over the PGs with an n-alkyl lower side chain. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.4 17-trifluoromethylphenyl-13,14-dihydro trinor PGF (17-TFM-PGF) is a typical “ring” analog reminiscent of the trifluoromethyl-phenoxy ring of Travoprost. The a chain of 17-TFM-PGF is saturated, making this compound a formal member of the one-series PGs. Recent work has shown that in the “ring” series of analogs, this modification has little impact on FP receptor binding.5 As an ocular hypotensive agent, it is expected that 17-TFM-PGF would act very much like the free acid of latanoprost.

1. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Surv Ophthalmol 45 S337-S345 (2001).

2. Stjernschantz, J.W. From PGF-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lecture. Invest Ophthamol Vis Sci 42(6) 1134-1145 (2001).

3. Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

4. Resul, B., Stjernschantz, J., No, K., et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents. J Med Chem 36 243-248 (1993).

5. deLong, M.A., Amburgey, J., Taylor, C., et al. Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues. Bioorg Med Chem Lett 10 1519-1522 (2000).

  • 17-TFM-PGF
Formal Name 9α,​11α,​15S-​trihydroxy-​17-​trifluoromethylphenyl-​18,​19,​20-​trinor-​prostan-​1-​oic acid
CAS Number 1027401-98-4
Molecular Formula C24H35F3O5
Formula Weight 460.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Copy SMILES to clipboard
InCHI Code
Copy InCHI code to clipboard
Copy InCHI key to clipboard

Download free InCHI Key generation software

17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-08-02. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

17-trifluoromethylphenyl trinor Prostaglandin F methyl ester
Prostaglandin F


Batch-specific Information

Get batch-specific data and documents by batch number

Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


Please wait...