COX-1 (mouse) Polyclonal Antibody

Cayman Chemical Item Number 160109

Cyclooxygenase 1; Prostaglandin H Synthase 1; PGHS-1

COX-1 (mouse) Polyclonal Antibody

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Description

Antigen: mouse COX-1 amino acids 274-288 (LMRYPPGVPPERQMA) · Host: rabbit · Application(s): WB and IHC · COX-1 is responsible for the production of prostaglandins essential for the normal function of many organs including the stomach and kidney.1 COX-1 is generally described as being constitutively expressed, although COX-1 expression is regulated developmentally and in response to a variety of other stimuli.2,3,4,5 Mouse COX-1 has a molecular weight of 70,000 and is expressed in nearly all tissues of the body.6,1

1 Smith, W.L., Garavito, R.M., and DeWitt, D.L. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem 271 33157-33160 (1996).

2 Brannon, T.S., North, A.J., Wells, L.B., et al. Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression. J Clin Invest 93 2230-2235 (1994).

3 Funk, C.D., Funk, L.B., Kennedy, M.E., et al. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J 5 2304-2312 (1991).

4 Samet, J.M., Fasano, M.B., Fonteh, A.N., et al. Selective induction of prostaglandin G/H synthase I by stem cell factor and dexamethasone in mast cells. J Biol Chem 270 8044-8049 (1995).

5 Hla, T., and Maciag, T. Cyclooxygenase gene expression is down-regulated by heparin-binding (acidic fibroblast) growth factor-1 in human endothelial cells. J Biol Chem 266 24059-24063 (1991).

6 DeWitt, D.L., El-Harith, E.A., Kraemer, S.A., et al. The aspirin and heme-binding sites of ovine and murine prostaglandin endoperoxide synthases. J Biol Chem 265 5192-5198 (1990).

Synonyms
  • Cyclooxygenase 1
  • Prostaglandin H Synthase 1
  • PGHS-1
Formal Name
Formulation Peptide affinity-purified rabbit IgG
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Specificity
Mouse COX-1 +
Rat COX-1 +
Human COX-1 -
Ovine COX-1 -
COX-2 (all species) -
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Pricing updated 2014-04-24. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

COX-1 Monoclonal Antibody (Clone CX111)
COX-1 (mouse) Blocking Peptide
COX-1 (ovine) Polyclonal Antiserum
Goat Anti-Rabbit IgG HRP
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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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