Prostaglandin F methyl ester

Cayman Chemical Item Number 16011

PGF methyl ester (CAS 33854-16-9)

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Prostaglandin F methyl ester (PGF methyl ester) is an analog of PGF in which the C-1 carboxyl group has been esterified as the methyl ester. PGF methyl ester was one of the first PG esters shown to have ocular hypotensive activity.1 This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 µg dose of PGF-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.1

1. Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res 38 181-184 (1984).

  • PGF methyl ester
Formal Name 9α,​11α,​15S-​trihydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ methyl ester
CAS Number 33854-16-9
Molecular Formula C21H36O5
Formula Weight 368.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Prostaglandin F methyl ester is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $25.00 $0.00
1 mg $48.00 $0.00
5 mg $200.00 $0.00
10 mg $350.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-03. Prices are subject to change without notice.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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