Prostaglandin F methyl ester

Cayman Chemical Item Number 16011

PGF methyl ester (CAS 33854-16-9)

Prostaglandin F2α methyl ester (CAS 33854-16-9)

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Description

Prostaglandin F methyl ester (PGF methyl ester) is an analog of PGF in which the C-1 carboxyl group has been esterified as the methyl ester. PGF methyl ester was one of the first PG esters shown to have ocular hypotensive activity.1 This compound continues to be a standard by which other ocular hypotensive PG prodrugs are evaluated. The methyl ester is about 4-5 times more potent than the free acid, PGF. This difference is attributed to improved corneal penetration, and a depot effect of prolonged retention of the ester form of the compound in ocular tissue. A 2.5 µg dose of PGF-OMe applied to the eyes of cats results in a 6-8 mm Hg reduction in IOP.1

1 Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res 38 181-184 (1984).

Synonyms
  • PGF methyl ester
Formal Name 9α,​11α,​15S-​trihydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ methyl ester
CAS Number 33854-16-9
Molecular Formula C21H36O5
Formula Weight 368.5
Formulation A solution in methyl acetate
Purity >98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/[C@H]​1[C@H]​(O)​C[C@H]​(O)​[C@@H]​1C/C=C\CCCC(OC)​=O
InCHI Code
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​1S/C21H36O5/c1-3-4-7-10-16(22)​13-14-18-17(19(23)​15-20(18)​24)​11-8-5-6-9-12-21(25)​26-2/h5,8,13-14,16-20,22-24H,3-4,6-7,9-12,15H2,1-2H3/b8-5-,14-13+/t16-,17+,18+,19-,20+/m0/s1
InCHI Key
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PJDMFGSFLLCCAO-NVRZHKMMSA-N

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Prostaglandin F2α methyl ester is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $25.00 $0.00
1 mg $48.00 $0.00
5 mg $200.00 $0.00
10 mg $350.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-17. Prices are subject to change without notice.

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