Prostaglandin F Alcohol methyl ether

Cayman Chemical Item Number 16014

AGN 191129; PGF-OMe (CAS 143656-18-2)

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Description

Prostaglandin F alcohol methyl ether (PGF-OMe) is an analog of PGF in which the C-1 carboxyl group has been replaced an O-methyl ether. The compound is reported to retain ocular hypotensive properties,1 but the receptors which mediate this activity have not been clearly documented.2

1. Woodward, D.F., and Chan, M.F. Preparation of PGF-1 alcohols as ocular hypotensives. 38204 1-12 (1993).

2. Woodward, D.F., Krauss, A.H., Chen, J., et al. Replacement of the carboxylic acid group of prostaglandin F with a hydroxyl or methoxy substituent provides biologically unique compounds. Br J Pharmacol 130 1933-1943 (2000).

Synonyms
  • AGN 191129
  • PGF-OMe
Formal Name 1-​methoxy-​9α,​11α,​15S-​trihydroxyprosta-​5Z,​13E-​diene
CAS Number 143656-18-2
Molecular Formula C21H38O4
Formula Weight 354.5
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@H]​(C/C=C\CCCCOC)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@H]​(O)​C1
InCHI Code
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​1S/C21H38O4/c1-3-4-8-11-17(22)​13-14-19-18(20(23)​16-21(19)​24)​12-9-6-5-7-10-15-25-2/h6,9,13-14,17-24H,3-5,7-8,10-12,15-16H2,1-2H3/b9-6-,14-13+/t17-,18+,19+,20-,21+/m0/s1
InCHI Key
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VWEVSUSNDAHANL-GPPPFWBLSA-N

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Prostaglandin F Alcohol methyl ether is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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