Prostaglandin F ethyl amide

Cayman Chemical Item Number 16016

PGF-NEt; Dinoprost ethyl amide (CAS 54130-36-8)

See more


Prostaglandin F ethyl amide (PGF-NEt) is an analog of PGF in which the C-1 carboxyl group has been modified to an N-ethyl amide. PG esters have been shown to have ocular hypotensive activity.1 PG N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs.2 Although it has been claimed that PG ethyl amides are not converted to the free acids in vivo,2 studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 µg/g corneal tissue/hr.3 PGF-NEt would be expected to show the typical intraocular effects of PGF free acid, but with the much slower hydrolysis pharmacokinetics of the PG N-amides.

1. Bito, L.Z. Comparison of the ocular hypotensive efficacy of eicosanoids and related compounds. Exp Eye Res 38 181-184 (1984).

2. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Surv Ophthalmol 45 S337-S345 (2001).

3. Maxey, K.M., Johnson, J., Camras, C.B., et al. The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Surv Ophthalmol 47(4) 34-40 (2002).

  • PGF-NEt
  • Dinoprost ethyl amide
Formal Name N-​ethyl-​9α,​11α,​15S-​trihydroxy-​prosta-​5Z,​13E-​dien-​1-​amide
CAS Number 54130-36-8
Molecular Formula C22H39NO4
Formula Weight 381.6
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Copy SMILES to clipboard
InCHI Code
Copy InCHI code to clipboard
Copy InCHI key to clipboard

Download free InCHI Key generation software

Prostaglandin F ethyl amide is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $42.00 $0.00
5 mg $189.00 $0.00
10 mg $336.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-08-01. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

16-phenoxy Prostaglandin F ethyl amide
17-chlorophenyl trinor Prostaglandin F ethyl amide
17-phenyl trinor Prostaglandin F ethyl amide
Prostaglandin F
Prostaglandin F dimethyl amide
Prostaglandin F serinol amide
Show all 7 Hide all but first 3


Batch-specific Information

Get batch-specific data and documents by batch number

Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


Please wait...