Prostaglandin F isopropyl ester

Cayman Chemical Item Number 16030

Dinoprost isopropyl ester; PGF isopropyl ester (CAS 53764-90-2)

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Description

PGF isopropyl ester is an ester prodrug of PGF with enhanced lipid solubility. Due to better membrane penetration, PGF isopropyl ester is more suitable than PGF or PGF tromethamine salt for topical application in studies on intraocular pressure. The ester functionality is readily hydrolyzed in vivo to release the active compound PGF. When administered topically to the eyes of cynomolgus monkeys, a 5 µg dose reduces intraocular pressure by 68% after the fourth day of treatment.1

1. Crawford, K.S., and Kaufman, P.L. Dose-related effects of prostaglandin F isopropyl ester on intraocular pressure, refraction, and pupil diameter in monkeys. Invest Ophthamol Vis Sci 32 510-519 (1991).

Synonyms
  • Dinoprost isopropyl ester
  • PGF isopropyl ester
Formal Name 9α,​11α,​15S-​trihydroxy-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ isopropyl ester
CAS Number 53764-90-2
Molecular Formula C23H40O5
Formula Weight 396.6
Formulation A solution in methyl acetate
Purity >98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O[C@@H]​1[C@H]​(C/C=C\CCCC(OC(C)​C)​=O)​[C@@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@H]​(O)​C1
InCHI Code
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​1S/C23H40O5/c1-4-5-8-11-18(24)​14-15-20-19(21(25)​16-22(20)​26)​12-9-6-7-10-13-23(27)​28-17(2)​3/h6,9,14-15,17-22,24-26H,4-5,7-8,10-13,16H2,1-3H3/b9-6-,15-14+/t18-,19+,20+,21-,22+/m0/s1
InCHI Key
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FPABVZYYTCHNMK-YNRDDPJXSA-N

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Prostaglandin F isopropyl ester is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $57.00 $0.00
5 mg $257.00 $0.00
10 mg $456.00 $0.00
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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA

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