DcR2 Polyclonal Antibody

Cayman Chemical Item Number 160755

TRAIL-R4; TRUNDD

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Description

Antigen: human DcR2 precursor amino acids 249-263 (GGPERVHRVLFRRRS) · Host: rabbit · Application(s): WB · Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor.1,2,3 Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD.4,5,6 DcR2 has an extracellular TRAIL-binding domain but lacks an intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuates TRAIL-induced apoptosis.

1. Pan, G., O'Rourke, K., Chinnaiyan, A.M., et al. The receptor for the cytotoxic ligand TRAIL. Science 276 111-113 (1997).

2. Pan, G., Ni, J., Wei, Y., et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277 815-817 (1997).

3. Sheridan, J.P., Marsters, S.A., Pitti, R.M., et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277 818-821 (1997).

4. Marsters, S.A., Sheridan, J.P., Pitti, R.M., et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol 7 1003-1006 (1997).

5. Degli-Esposti, M.A., Dougall, W.C., Smolak, P.J., et al. The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 7 813-820 (1997).

6. Pan, G., Ni, J., Yu, G., et al. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett 424 41-45 (1998).

Synonyms
  • TRAIL-R4
  • TRUNDD
Formulation 100 µg affinity-purified IgG in 200 µl PBS containing 0.02% sodium azide
Stability 1 year
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere
Specificity
Human DcR2 +

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