DcR2 Polyclonal Antibody
Item № 160755
1 ea $259.00 $0.00

Pricing updated 2016-02-06. Prices are subject to change without notice.

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  • TRAIL-R4

Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor.1,2,3 Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD.4,5,6 DcR2 has an extracellular TRAIL-binding domain but lacks an intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuates TRAIL-induced apoptosis.

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Technical Information
  • TRAIL-R4
Immunogen human DcR2 precursor amino acids 249-263 (GGPERVHRVLFRRRS){6871,6891,6883}
Formulation 100 µg affinity-purified IgG in 200 µl PBS containing 0.02% sodium azide
Host rabbit
Applications WB
Species Reactivity
  • (+) Human DcR2

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage 4°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 83 Kb PDF

Download Safety Data Sheet (SDS) 26 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Pan, G., O'Rourke, K., Chinnaiyan, A.M., et al. The receptor for the cytotoxic ligand TRAIL. Science 276 111-113 (1997).

2. Pan, G., Ni, J., Wei, Y., et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 277 815-817 (1997).

3. Sheridan, J.P., Marsters, S.A., Pitti, R.M., et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 277 818-821 (1997).

4. Marsters, S.A., Sheridan, J.P., Pitti, R.M., et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr Biol 7 1003-1006 (1997).

5. Degli-Esposti, M.A., Dougall, W.C., Smolak, P.J., et al. The novel receptor TRAIL-R4 induces NF-κB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain. Immunity 7 813-820 (1997).

6. Pan, G., Ni, J., Yu, G., et al. TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling. FEBS Lett 424 41-45 (1998).

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