8-iso-15-keto Prostaglandin F

Cayman Chemical Item Number 16390

8-epi-15-keto PGF; 8-iso-15-keto PGF (CAS 191919-01-4)

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8-iso-15-keto Prostaglandin F (8-iso-15-keto PGF) is a metabolite of the isoprostane 8-iso PGF in rabbits, monkeys, and humans. 8-isoprostane (8-iso PGF) is a prostaglandin-like product of non-specific lipid peroxidation.1 In both humans and monkeys, exogenously infused 8-iso PGF is converted primarily to metabolites having 2 or 4 carbon atoms removed from the top side chain by β-oxidation.2 A similar pattern is observed when tritiated 8-iso PGF is infused into rabbits.3 Early in the infusion (within 1-2 minutes) 8-iso -15-keto PGF was a major component of the metabolite profile, which was comprised mostly of unmetabolized 8-iso PGF. 8-iso -15-keto PGF is a vasoconstrictor when tested on the rat isolated thoracic aorta, acting via the TP (thromboxane) receptor.4

1. Morrow, J.D., Hill, K.E., Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87 9383-9387 (1990).

2. Chiabrando, C., Valagussa, A., Rivalta, C., et al. Identification and measurement of endogenous β-oxidation metabolites of 8-epi-prostaglandin F2a. J Biol Chem 274 1313-1319 (1999).

3. Basu, S. Metabolism of 8-iso-prostaglandin F. FEBS Lett 428 32-36 (1998).

4. Cracowski, J., Camus, L., Durand, T., et al. Response of rat thoracic aorta to F2-isoprostane metabolites. J Cardiovasc Pharmacol 39 396-403 (2002).

  • 8-epi-15-keto PGF
  • 8-iso-15-keto PGF
Formal Name 9α,​11α-​dihydroxy-​15-​oxo-​(8β)-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 191919-01-4
Molecular Formula C20H32O5
Formula Weight 352.5
Formulation A solution in methyl acetate
Purity ≥95%
λmax 230 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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8-iso-15-keto Prostaglandin F is available in the following screening library:

Size Price Quantity Subtotal
100 µg $25.00 $0.00
500 µg $75.00 $0.00
1 mg $138.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-04. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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8-iso-15-keto Prostaglandin F


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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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