15(R)-15-methyl Prostaglandin F

Cayman Chemical Item Number 16730

15(R)-15-methyl PGF (CAS 35864-81-4)

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15(R)-15-methyl PGF is a metabolically stable analog of PGF. 15(R)-15-methyl PGF is an inactive, prodrug PGF agonist designed for activation by gastric acid after oral administration. Acid-catalyzed epimerization of 15(R)-15-methyl PGF converts it into the active 15(S)-isomer.1,2 The 15(S)-isomer induces luteolysis when injected in rhesus monkeys at a dose of about 12 mg/animal, while the 15(R)-isomer does not.3

1. Plaisted, S.M., DeZwaan, J., and Snider, B.G. High-performance liquid chromatographic determination of acid-catalyzed degradation products of methyl carboprost in a polymeric controlled-release device. J Chromatogr 314 369-377 (1984).

2. Hamberg, M., Zhang, L., and Bergström, S. On the pH-dependent degradation of 15(S)-15 methyl-prostaglandin F (carboprost). Eur J Pharm Sci 3 27-38 (1995).

3. Wilks, J.W. Inhibition of the monkey corpus luteum with 15-methyl prostaglandins. Prostaglandins 20 793-805 (1980).

  • 15(R)-15-methyl PGF
Formal Name 9α,​11α,​15R-​trihydroxy-​15-​methyl-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 35864-81-4
Molecular Formula C21H36O5
Formula Weight 368.5
Formulation A solution in methyl acetate
Purity ≥95%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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15(R)-15-methyl Prostaglandin F is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-04. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

Related Products

15(R)-15-methyl Prostaglandin F methyl ester
15(S)-15-methyl Prostaglandin F
15(S)-15-methyl Prostaglandin F methyl ester
Prostaglandin F
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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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