AL 8810

Cayman Chemical Item Number 16735

(CAS 246246-19-5)

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Sold under license from Alcon.


AL 8810 is an 11β-fluoro analog of PGF which acts as a potent and selective antagonist at the FP receptor.1 AL 8810 has weak intrinsic agonist activity on FP receptor preparations in the 200-300 nM range, yet it fully antagonizes the activity of the potent FP receptor agonist fluprostenol at this concentration, with EC50 values of approximately 430 nM. AL 8810 fully antagonized the bimatoprost-induced calcium mobilization in Swiss 3T3 fibroblasts at 100 µM, indicating that bimatoprost acts as an FP agonist in this preparation.2 The Ki for the inhibition of several potent agonists at the cloned human ciliary body FP receptor is in the range of 1-2 µM.3

1. Griffen, B.W., Klimko, P., Crider, J.Y., et al. AL-8810: A novel prostaglandin F analog with selective antagonist effects at the prostaglandin F (FP) receptor. J Pharmacol Exp Ther 290(3) 1278-1284 (1999).

2. Sharif, N.A., Williams, G.W., and Kelly, C.R. Bimatoprost and its free acid are prostaglandin FP receptor agonists. Eur J Pharmacol 432 211-213 (2001).

3. Sharif, N.A., Kelly, C.R., and Crider, J.Y. Agonist activity of Bimatoprost, Travoprost, Latanoprost, Unoprostone isopropyl ester and other prostaglandin analogs at the cloned human ciliary body FP prostaglandin receptor.. J Ocul Pharmacol 18 313-324 (2002 Feb 27).

Formal Name 9α,​15R-​dihydroxy-​11.beta-​fluoro-​15-​(2,​3-​dihydro-​1H-​inden-​2-​yl)-​16,​17,​18,​19,​20-​pentanor-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 246246-19-5
Molecular Formula C24H31O4F
Formula Weight 402.5
Formulation A crystalline solid
Purity ≥98%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Size Price Quantity Subtotal
1 mg $84.00 $0.00
5 mg $378.00 $0.00
10 mg $672.00 $0.00
25 mg $1,470.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-31. Prices are subject to change without notice.

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Sold under license from Alcon.

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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