Cloprostenol (sodium salt)
Item № 16764
CAS № 55028-72-3
Purity ≥98%
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1 mg $37.00 $0.00
5 mg $167.00 $0.00
10 mg $241.00 $0.00

Pricing updated 2015-10-04. Prices are subject to change without notice.

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  • (±)-16-m-chlorophenoxy tetranor PGF
  • (±)-16-m-chlorophenoxy tetranor Prostaglandin F
  • DL-Cloprostenol

Cloprostenol (sodium salt) is a more water solute, crystalline form of cloprostenol than the free acid. Cloprostenol is a synthetic analog of prostaglandin F (PGF). It is 200 times and 100 times more potent than PGF in terminating pregnancy in hamsters and rats, respectively, without the side effects associated with PGF.1 The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.1 Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10−12 M.2

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Technical Information
Formal Name (±)-9α,11α,15R-trihydroxy-16-(3-chlorophenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid, sodium salt
CAS Number 55028-72-3
  • (±)-16-m-chlorophenoxy tetranor PGF
  • (±)-16-m-chlorophenoxy tetranor Prostaglandin F
  • DL-Cloprostenol
Molecular Formula C22H28ClO6 • Na
Formula Weight 446.9
Purity ≥98%
Formulation A crystalline solid
λmax 275, 282 nm
SMILES O[C@@H]1[C@H](C/C=C\CCCC([O-])=O)[C@@H](/C=C/[C@@H](O)COC2=CC=CC(Cl)=C2)[C@H](O)C1.[Na+]
InChI Code 1S/C22H29ClO6.Na/c23-15-6-5-7-17(12-15)29-14-16(24)10-11-19-18(20(25)13-21(19)26)8-3-1-2-4-9-22(27)28;/h1,3,5-7,10-12,16,18-21,24-26H,2,4,8-9,13-14H2,(H,27,28);/q;+1/p-1/b3-1-,11-10+;/t16-,18-,19-,20+,21-;/m1./s1

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
Stability 2 years
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References & Background Reading
Product Description References

1. Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F. Nature 250 330-331 (1974).

2. Serrero, G., and Lepak, N.M. Prostaglandin F receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochem Biophys Res Commun 233 200-202 (1997).

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