(+)-Cloprostenol (sodium salt)

Cayman Chemical Item Number 16766

D-Cloprostenol; (+)-16-m-chlorophenoxy tetranor PGF; (+)-16-m-chlorophenoxy tetranor Prostaglandin F (CAS 62561-03-9)

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(+)-Cloprostenol (sodium salt) is a more water soluble, crystalline form of (+)-cloprostenol. (+)-Cloprostenol is a synthetic analog of prostaglandin F (PGF). It is an FP receptor agonist and a potent luteolytic agent in rats and hamsters. (+)-Cloprostenol is the optically active, 15(R) enantiomer of cloprostenol responsible for the majority of its biological activity. Cloprostenol is 200 times and 100 times more potent than PGF in terminating pregnancy in hamsters and rats, respectively without the side effects associated with PGF.1 The subcutaneous dose required for interrupting early pregnancy is species dependent, requiring approximately 1.25 µg/kg and 270 µg/kg in hamsters and rats, respectively.1 Cloprostenol is also a potent inhibitor of rat adipose precursor differentiation in primary cultures with an IC50 of 3 x 10−12 M.2

1. Dukes, M., Russell, W., and Walpole, A.L. Potent luteolytic agents related to prostaglandin F. Nature 250 330-331 (1974).

2. Serrero, G., and Lepak, N.M. Prostaglandin F receptor (FP receptor) agonists are potent adipose differentiation inhibitors for primary culture of adipocyte precursors in defined medium. Biochem Biophys Res Commun 233 200-202 (1997).

  • D-Cloprostenol
  • (+)-16-m-chlorophenoxy tetranor PGF
  • (+)-16-m-chlorophenoxy tetranor Prostaglandin F
Formal Name (+)-​9α,​11α,​15R-​trihydroxy-​16-​(3-​chlorophenoxy)-​17,​18,​19,​20-​tetranor-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ sodium salt
CAS Number 62561-03-9
Molecular Formula C22H28ClO6 • Na
Formula Weight 446.9
Formulation A crystalline solid
Purity ≥98%
λmax 275, 282 nm
Stability 2 years
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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(+)-Cloprostenol (sodium salt) is available in the following screening library:

Size Price Quantity Subtotal
1 mg $49.00 $0.00
5 mg $221.00 $0.00
10 mg $392.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-01. Prices are subject to change without notice.

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Related Products

(+)-15-epi Cloprostenol
(+)-Cloprostenol isopropyl ester
(+)-Cloprostenol methyl amide
(+)-Cloprostenol methyl ester
Cloprostenol (sodium salt)
Prostaglandin F
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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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