15-keto Fluprostenol isopropyl ester

Cayman Chemical Item Number 16786

15-keto Travoprost (CAS 404830-45-1)

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Travoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1,2 Oxidation of the C-15 hydroxyl group without isopropyl ester hydrolysis produces 15-keto fluprostenol isopropyl ester (15-keto travoprost). 15-keto Travoprost is a potential metabolite of travoprost when administered to intact animals. 15-keto Travoprost is also one of the common minor impurities found in commercial preparations of the bulk drug compound. In general, F-series prostaglandin analogs with a 15-keto functional group lose a great deal of their FP receptor binding affinity, but retain enough to show a continued weak IOP hypotensive response.3 The efficacy of 15-keto travoprost as an ocular hypotensive has not been established.

1. Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

2. Hellberg, M.R., Sallee, V.L., Mclaughlin, M.A., et al. Preclinical efficacy of travoprost, a potent and selective FP prostaglandin receptor agonist. J Ocul Pharmacol Ther 17(5) 421-432 (2001).

3. Taniguchi, T., Haque, M.S.R., Sugiyama, K., et al. Ocular hypotensive mechanism of topical isopropyl unoprostone, a novel prostaglandin metabolite-related drug, in rabbits. J Ocul Pharmacol 12 489-498 (1996).

  • 15-keto Travoprost
Formal Name (±)-​15-​oxo-​9α,​11α-​dihydroxy-​16-​(3-​(trifluoromethyl)phenoxy)-​17,​18,​19,​20-​tetranor-​prosta-​5Z,​13E-​dien-​1-​oic acid,​ isopropyl ester
CAS Number 404830-45-1
Molecular Formula C26H33F3O6
Formula Weight 498.5
Formulation A solution in methyl acetate
Purity ≥98%
λmax 224 nm
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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15-keto Fluprostenol isopropyl ester is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $71.00 $0.00
5 mg $320.00 $0.00
10 mg $568.00 $0.00
25 mg $1,243.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-29. Prices are subject to change without notice.

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Related Products

13(R),14(R)-epoxy Fluprostenol isopropyl ester
13(S),14(S)-epoxy Fluprostenol isopropyl ester


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