17-trifluoromethylphenyl trinor Prostaglandin F

Cayman Chemical Item Number 16890

17-trifluoromethylphenyl trinor PGF (CAS 221246-34-0)

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A number of 17-phenyl trinor prostaglandin F (17-phenyl trinor PGF) derivatives have been approved for the treatment of glaucoma.1,2,3 Of these, the unsubstituted or meta-substituted aromatic derivatives are the most potent FP receptor agonists.4 17-trifluoromethylphenyl trinor PGF bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl trinor PGF would act very much like the free acid of travoprost. 17-phenyl trinor PGF is a potent luteolytic and abortifacient, with a potency equal to or greater than fluprostenol and cloprostenol.4

1. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Surv Ophthalmol 45 S337-S345 (2001).

2. Stjernschantz, J.W. From PGF-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lecture. Invest Ophthamol Vis Sci 42(6) 1134-1145 (2001).

3. Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

4. deLong, M.A., Amburgey, J., Taylor, C., et al. Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues. Bioorg Med Chem Lett 10 1519-1522 (2000).

  • 17-trifluoromethylphenyl trinor PGF
Formal Name 9α,​11α,​15S-​trihydroxy-​17-​trifluoromethylphenyl-​18,​19,​20-​trinor-​prosta-​5Z,​13E-​dien-​1-​oic acid
CAS Number 221246-34-0
Molecular Formula C24H31O5F3
Formula Weight 456.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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17-trifluoromethylphenyl trinor Prostaglandin F is available in the following screening library:

Size Price Quantity Subtotal
1 mg $49.00 $0.00
5 mg $221.00 $0.00
10 mg $392.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-06. Prices are subject to change without notice.

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15(S)-15-methyl Prostaglandin F isopropyl ester
17-phenyl trinor Prostaglandin F
17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F
17-trifluoromethylphenyl trinor Prostaglandin F isopropyl ester
17-trifluoromethylphenyl trinor Prostaglandin F methyl ester
(+)-Cloprostenol methyl amide
(+)-Cloprostenol methyl ester
Fluprostenol isopropyl ester
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