17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F

Cayman Chemical Item Number 16895

17-trifluoromethylphenyl-13,14-dihydro trinor PGF (CAS 294856-01-2)

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A number of 17-phenyl trinor prostaglandin F (17-phenyl trinor PGF) derivatives have been approved for the treatment of glaucoma.1,2,3 Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects.4 17-trifluoromethylphenyl-13,14-dihydro trinor PGF bears an aromatic ring which is reminiscent of the trifluoromethyl-phenoxy ring of travoprost ((+)-fluprostenol isopropyl ester). As an ocular hypotensive agent, it would be expected that 17-trifluoromethylphenyl-13,14-dihydro trinor PGF would act very much like the free acid of latanoprost.

1. Woodward, D.F., Krauss, A.H., Chen, J., et al. The pharmacology of Bimatoprost (Lumigan™). Surv Ophthalmol 45 S337-S345 (2001).

2. Stjernschantz, J.W. From PGF-isopropyl ester to latanoprost: A review of the development of xalatan. The proper lecture. Invest Ophthamol Vis Sci 42(6) 1134-1145 (2001).

3. Sorbera, L.A., and Castañer, J. Travoprost. Drugs Future 25 41-45 (2000).

4. Resul, B., Stjernschantz, J., No, K., et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents. J Med Chem 36 243-248 (1993).

  • 17-trifluoromethylphenyl-13,14-dihydro trinor PGF
Formal Name 9α,​11α,​15R-​trihydroxy-​17-​(3-​(trifluoromethyl)phenyl)-​18,​19,​20-​trinor-​prosta-​5Z-​en-​1-​oic acid
CAS Number 294856-01-2
Molecular Formula C24H33O5F3
Formula Weight 458.5
Formulation A solution in methyl acetate
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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17-trifluoromethylphenyl-13,14-dihydro trinor Prostaglandin F is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $56.00 $0.00
5 mg $252.00 $0.00
10 mg $448.00 $0.00
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Pricing updated 2015-07-30. Prices are subject to change without notice.

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Related Products

17-phenyl trinor Prostaglandin F
17-trifluoromethylphenyl trinor Prostaglandin F
17-trifluoromethylphenyl trinor Prostaglandin F methyl ester
Fluprostenol isopropyl ester
Fluprostenol isopropyl ester-d4 New
Latanoprost (free acid)
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