6α-Prostaglandin I1 • 6α-<wbr/>PGI<sub>1</sub>; 5,6α-<wbr/>dihydro PGI<sub>2</sub> (CAS 62777-90-6) (Inchi key RJADQDXZYFCVHV-WDONHGPHSA-N) || Cayman Chemical | Supplier
6α-Prostaglandin I1
Item № 18110
CAS № 62777-90-6
Purity ≥99%
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CART TOTAL $0.00
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00

Pricing updated 2015-08-29. Prices are subject to change without notice.

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Description
Synonyms
  • 6α-PGI1
  • 5,6α-dihydro PGI2

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response.1 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).2

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Technical Information
Formal Name 6R,​9α-​epoxy-​11α,​15S-​dihydroxy-​prost-​13E-​en-​1-​oic acid
CAS Number 62777-90-6
Synonyms
  • 6α-PGI1
  • 5,6α-dihydro PGI2
Molecular Formula C20H34O5
Formula Weight 354.5
Purity ≥99%
Formulation A crystalline solid
SMILES O[C@H]​1[C@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@@H]​(C[C@]​(CCCCC(O)​=O)​([H]​)​O2)​[C@@H]​2C1
InChI Code ​1S/C20H34O5/c1-2-3-4-7-14(21)​10-11-16-17-12-15(8-5-6-9-20(23)​24)​25-19(17)​13-18(16)​22/h10-11,14-19,21-22H,2-9,12-13H2,1H3,(H,23,24)​/b11-10+/t14-,15+,16+,17+,18+,19-/m0/s1
InChI Key RJADQDXZYFCVHV-WDONHGPHSA-N

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
Product Downloads & Resources
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Download Product Insert 164 Kb PDF

Download Safety Data Sheet (SDS) 22 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. Patrono, C., Rotella, C.M., Toccafondi, R.S., et al. Prostacyclin stimulates the adenylate cyclase system of human thyroid tissue. Prostaglandins 22(1) 105-115 (1981).

2. Whittle, B.J.R., and Moncada, S. Prostacyclin and its analogues for the therapy of thromboembolic disorders. Adv Exp Med Biol 164 193-209 (1984).

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