6α-Prostaglandin I1

Cayman Chemical Item Number 18110

6α-PGI1; 5,6α-dihydro PGI2 (CAS 62777-90-6)

6α-Prostaglandin I1 (CAS 62777-90-6)

See more

Description

6α-Prostaglandin I1 (6α-PGI1) is a stable Prostaglandin I2 (PGI2) analog resistant to hydrolysis in aqueous solutions. 6α-PGI1 promotes cyclic AMP accumulation in human thyroid slices and cells in a concentration dependent manner. However, it is about 10-fold less potent than the β-isomer and 100-fold less potent than PGI2 in eliciting the response.1 6α-PGI1 exhibits an IC50 of 350 ng/ml for inhibition of ADP-induced platelet aggregation, which is nearly 900-fold higher than that observed for PGI2 (0.4 ng/ml).2

1 Patrono, C., Rotella, C.M., Toccafondi, R.S., et al. Prostacyclin stimulates the adenylate cyclase system of human thyroid tissue. Prostaglandins 22(1) 105-115 (1981).

2 Whittle, B.J.R., and Moncada, S. Prostacyclin and its analogues for the therapy of thromboembolic disorders. Adv Exp Med Biol 164 193-209 (1984).

Synonyms
  • 6α-PGI1
  • 5,6α-dihydro PGI2
Formal Name 6R,​9α-​epoxy-​11α,​15S-​dihydroxy-​prost-​13E-​en-​1-​oic acid
CAS Number 62777-90-6
Molecular Formula C20H34O5
Formula Weight 354.5
Formulation A crystalline solid
Purity ≥99%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
O[C@H]​1[C@H]​(/C=C/[C@@H]​(O)​CCCCC)​[C@@H]​(C[C@]​(CCCCC(O)​=O)​([H]​)​O2)​[C@@H]​2C1
InCHI Code
Copy InCHI code to clipboard
​1S/C20H34O5/c1-2-3-4-7-14(21)​10-11-16-17-12-15(8-5-6-9-20(23)​24)​25-19(17)​13-18(16)​22/h10-11,14-19,21-22H,2-9,12-13H2,1H3,(H,23,24)​/b11-10+/t14-,15+,16+,17+,18+,19-/m0/s1
InCHI Key
Copy InCHI key to clipboard
RJADQDXZYFCVHV-WDONHGPHSA-N

Download free InCHI Key generation software

6α-Prostaglandin I1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
Bulk Contact
Cart Total $0.00

Please Login or Register to use this page.

Pricing updated 2014-04-16. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

6β-Prostaglandin I1
Prostaglandin I2 (sodium salt)

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Other Resources
About Cayman Management Team Company Profile ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map Conference Travel Grants

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2014 Cayman Chemical Company

Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research · Buy now! · Analytical testing services and custom synthesis also available

Lost password?