6β-Prostaglandin I1

Cayman Chemical Item Number 18120

6β-PGI1; 5,6β-dihydro PGI2 (CAS 62770-50-7)

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Description

6β 6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.1,2

1. Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 19 605-627 (1980).

2. Blair, I.A., Hensby, C.N., and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships. Br J Pharmacol 69 519-525 (1980).

Synonyms
  • 6β-PGI1
  • 5,6β-dihydro PGI2
Formal Name 6S,​9α-​epoxy-​11α,​15S-​dihydroxy-​prost-​13E-​en-​1-​oic acid
CAS Number 62770-50-7
Molecular Formula C20H34O5
Formula Weight 354.5
Formulation A crystalline solid
Purity ≥99%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/[C@H]​1[C@H]​(O)​C[C@H]​2[C@@H]​1C[C@@]​(CCCCC(O)​=O)​([H]​)​O2
InCHI Code
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​1S/C20H34O5/c1-2-3-4-7-14(21)​10-11-16-17-12-15(8-5-6-9-20(23)​24)​25-19(17)​13-18(16)​22/h10-11,14-19,21-22H,2-9,12-13H2,1H3,(H,23,24)​/b11-10+/t14-,15-,16+,17+,18+,19-/m0/s1
InCHI Key
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RJADQDXZYFCVHV-CBIPHORWSA-N

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6β-Prostaglandin I1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
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Related Products

6α-Prostaglandin I1
Prostaglandin I2 (sodium salt)

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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