6β-Prostaglandin I1

Cayman Chemical Item Number 18120

6β-PGI1; 5,6β-dihydro PGI2 (CAS 62770-50-7)

6β-Prostaglandin I1 (CAS 62770-50-7)

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Description

6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.1,2

1 Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 19 605-627 (1980).

2 Blair, I.A., Hensby, C.N., and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships. Br J Pharmacol 69 519-525 (1980).

Synonyms
  • 6β-PGI1
  • 5,6β-dihydro PGI2
Formal Name 6S,​9α-​epoxy-​11α,​15S-​dihydroxy-​prost-​13E-​en-​1-​oic acid
CAS Number 62770-50-7
Molecular Formula C20H34O5
Formula Weight 354.5
Formulation A crystalline solid
Purity ≥99%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/[C@H]​1[C@H]​(O)​C[C@H]​2[C@@H]​1C[C@@]​(CCCCC(O)​=O)​([H]​)​O2
InCHI Code
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​1S/C20H34O5/c1-2-3-4-7-14(21)​10-11-16-17-12-15(8-5-6-9-20(23)​24)​25-19(17)​13-18(16)​22/h10-11,14-19,21-22H,2-9,12-13H2,1H3,(H,23,24)​/b11-10+/t14-,15-,16+,17+,18+,19-/m0/s1
InCHI Key
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RJADQDXZYFCVHV-CBIPHORWSA-N

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6β-Prostaglandin I1 is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-17. Prices are subject to change without notice.

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Related Products

6α-Prostaglandin I1
Prostaglandin I2 (sodium salt)

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