6β-Prostaglandin I1 • 6β-<wbr/>PGI<sub>1</sub>; 5,6β-<wbr/>dihydro PGI<sub>2</sub> (CAS 62770-50-7) (Inchi key RJADQDXZYFCVHV-CBIPHORWSA-N) || Cayman Chemical | Supplier
6β-Prostaglandin I1
Item № 18120
CAS № 62770-50-7
Purity ≥99%
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1 mg $51.00 $0.00
5 mg $230.00 $0.00
10 mg $408.00 $0.00

Pricing updated 2015-08-30. Prices are subject to change without notice.

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  • 6β-PGI1
  • 5,6β-dihydro PGI2

6β 6β-PGI1 is a stable PGI2 analog resistant to hydrolysis in aqueous solutions. 6β-PGI1 has a much longer half-life than PGI2, but a greatly reduced molar potency for receptor mediated function. 6β-PGI1 has a Kact for adenylate cyclase in NCB-20 cells of 4.2 µM compared with 18 nM for PGI2. The potency for vasodilation and inhibition of platelet aggregation is about 1% of PGI2.1,2

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Technical Information
Formal Name 6S,​9α-​epoxy-​11α,​15S-​dihydroxy-​prost-​13E-​en-​1-​oic acid
CAS Number 62770-50-7
  • 6β-PGI1
  • 5,6β-dihydro PGI2
Molecular Formula C20H34O5
Formula Weight 354.5
Purity ≥99%
Formulation A crystalline solid
SMILES CCCCC[C@H]​(O)​/C=C/[C@H]​1[C@H]​(O)​C[C@H]​2[C@@H]​1C[C@@]​(CCCCC(O)​=O)​([H]​)​O2
InChI Code ​1S/C20H34O5/c1-2-3-4-7-14(21)​10-11-16-17-12-15(8-5-6-9-20(23)​24)​25-19(17)​13-18(16)​22/h10-11,14-19,21-22H,2-9,12-13H2,1H3,(H,23,24)​/b11-10+/t14-,15-,16+,17+,18+,19-/m0/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 2 years
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Download Product Insert 155 Kb PDF

Download Safety Data Sheet (SDS) 22 Kb PDF

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References & Background Reading
Product Description References

1. Whittle, B.J.R., Moncada, S., Whiting, F., et al. Carbacyclin - a potent stable prostacyclin analogue for the inhibition of platelet aggregation. Prostaglandins 19 605-627 (1980).

2. Blair, I.A., Hensby, C.N., and MacDermot, J. Prostacyclin-dependent activation of adenylate cyclase in a neuronal somatic cell hybrid: Prostanoid structure-activity relationships. Br J Pharmacol 69 519-525 (1980).

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