Piriprost (potassium salt) • U-<wbr/>60257B (CAS 88851-62-1) (Inchi key UFJDMFZMRXDIKI-FFGYHVHASA-M) || Cayman Chemical | Supplier
Piriprost (potassium salt)
Item № 18228
CAS № 88851-62-1
Purity >98%
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1 mg $41.00 $0.00
5 mg $185.00 $0.00
10 mg $328.00 $0.00
50 mg $1,435.00 $0.00

Pricing updated 2015-08-31. Prices are subject to change without notice.

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  • U-60257B

Piriprost is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.1 Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in inflammation and allergic responses.2

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Technical Information
Formal Name 1,​4(R),​5(R),​6-​tetrahydro-​5-​hydroxy-​4-​[(1E,​3S)-​3-​hydroxy-​1-​octenyl]-​1-​phenyl-​cyclopenta[b]pyrrole-​2-​pentanoic acid,​ monopotassium salt
CAS Number 88851-62-1
  • U-60257B
Molecular Formula C26H34NO4 • K
Formula Weight 463.7
Purity >98%
Formulation A crystalline solid
λmax 239 nm
SMILES CCCCC[C@H]​(O)​/C=C/[C@H]​1[C@H]​(O)​CC2=C1C=C(CCCCC([O-]​)​=O)​N2C3=CC=CC=C3.[K+]​
InChI Code ​1S/C26H35NO4.K/c1-2-3-5-13-21(28)​15-16-22-23-17-20(12-8-9-14-26(30)​31)​27(24(23)​18-25(22)​29)​19-10-6-4-7-11-19;/h4,6-7,10-11,15-17,21-22,25,28-29H,2-3,5,8-9,12-14,18H2,1H3,(H,30,31)​;/q;+1/p-1/b16-15+;/t21-,22+,25+;/m0./s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
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References & Background Reading
Product Description References

1. Cejic, S.S., and Kennedy, T.G. Examination of the effects of piriprost (U-60, 257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins 42 179-189 (1991).

2. McCormack, D.G., and Peterson, N.A.M. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis 139 100-105 (1989).

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