Piriprost (potassium salt)

Cayman Chemical Item Number 18228

U-60257B (CAS 88851-62-1)

Piriprost (potassium salt) (CAS 88851-62-1)

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Description

Piriprost is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.1 Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in inflammation and allergic responses.2

1 Cejic, S.S., and Kennedy, T.G. Examination of the effects of piriprost (U-60, 257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins 42 179-189 (1991).

2 McCormack, D.G., and Peterson, N.A.M. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis 139 100-105 (1989).

Synonyms
  • U-60257B
Formal Name 1,​4(R),​5(R),​6-​tetrahydro-​5-​hydroxy-​4-​[(1E,​3S)-​3-​hydroxy-​1-​octenyl]-​1-​phenyl-​cyclopenta[b]pyrrole-​2-​pentanoic acid,​ monopotassium salt
CAS Number 88851-62-1
Molecular Formula C26H34NO4 · K
Formula Weight 463.7
Formulation A crystalline solid
Purity >98%
λmax 239 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/[C@H]​1[C@H]​(O)​CC2=C1C=C(CCCCC([O-]​)​=O)​N2C3=CC=CC=C3.[K+]​
InCHI Code
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​1S/C26H35NO4.K/c1-2-3-5-13-21(28)​15-16-22-23-17-20(12-8-9-14-26(30)​31)​27(24(23)​18-25(22)​29)​19-10-6-4-7-11-19;/h4,6-7,10-11,15-17,21-22,25,28-29H,2-3,5,8-9,12-14,18H2,1H3,(H,30,31)​;/q;+1/p-1/b16-15+;/t21-,22+,25+;/m0./s1
InCHI Key
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UFJDMFZMRXDIKI-FFGYHVHASA-M

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Piriprost (potassium salt) is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $41.00 $0.00
5 mg $185.00 $0.00
10 mg $328.00 $0.00
50 mg $1,435.00 $0.00
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Pricing updated 2014-04-23. Prices are subject to change without notice.

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