Piriprost (potassium salt)

Cayman Chemical Item Number 18228

U-60257B (CAS 88851-62-1)

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Piriprost is a structural analog of prostaglandin I2 (PGI2) with low IP receptor-mediated activity. Piriprost inhibits 5-lipoxygenase with an IC50 around 100 µM, as measured by the release of 5-HETE from cultured myometrial cells.1 Piriprost inhibits the release of histamine and leukotrienes from isolated porcine lung cells with an IC50 of 0.11 µM, implicating its role in inflammation and allergic responses.2

1. Cejic, S.S., and Kennedy, T.G. Examination of the effects of piriprost (U-60, 257B) on alkaline phosphatase activity of rat endometrial stromal cells in vitro. Prostaglandins 42 179-189 (1991).

2. McCormack, D.G., and Peterson, N.A.M. The contrasting influence of two lipoxygenase inhibitors on hypoxic pulmonary vasoconstriction in anesthetized pigs. Am Rev Respir Dis 139 100-105 (1989).

  • U-60257B
Formal Name 1,​4(R),​5(R),​6-​tetrahydro-​5-​hydroxy-​4-​[(1E,​3S)-​3-​hydroxy-​1-​octenyl]-​1-​phenyl-​cyclopenta[b]pyrrole-​2-​pentanoic acid,​ monopotassium salt
CAS Number 88851-62-1
Molecular Formula C26H34NO4 • K
Formula Weight 463.7
Formulation A crystalline solid
Purity >98%
λmax 239 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Piriprost (potassium salt) is available in the following screening libraries:

Size Price Quantity Subtotal
1 mg $41.00 $0.00
5 mg $185.00 $0.00
10 mg $328.00 $0.00
50 mg $1,435.00 $0.00
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Cart Total $0.00

Pricing updated 2015-07-30. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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Ann Arbor, Michigan 48108 USA


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