Prostaglandin J2

Cayman Chemical Item Number 18500

PGJ2 (CAS 60203-57-8)

Prostaglandin J2 (CAS 60203-57-8)

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Description

Prostaglandin J2 (PGJ2) is formed from PGD2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.1 PGJ2 inhibits platelet aggregation with an IC50 of about 5-10 nM.2,3 PGJ2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.4 However, this activity has been attributed to further metabolites of PGJ2 and not the parent compound itself.

1 Fitzpatrick, F.A., and Wynalda, M.A. Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. J Biol Chem 258 11713-11718 (1983).

2 Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem 26 790-799 (1983).

3 Mahmud, I., Smith, D.L., Whyte, M.A., et al. On the identification and biological properties of prostaglandin J2. Prostaglandins Leukot Med 16 131-146 (1984).

4 Fukushima, M. Prostaglandin J2 - antitumor and anti-viral activities and the mechanisms involved. Eicosanoids 3 189-199 (1990).

Synonyms
  • PGJ2
Formal Name 11-​oxo-​15S-​hydroxy-​prosta-​5Z,​9,​13E-​trien-​1-​oic acid
CAS Number 60203-57-8
Molecular Formula C20H30O4
Formula Weight 334.5
Formulation A solution in methyl acetate
Purity ≥95%
λmax 216 nm
Stability 6 months
Storage -80°C
Shipping Dry ice in continental US; may vary elsewhere
SMILES
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CCCCC[C@H]​(O)​/C=C/[C@H]​([C@@H]​(C/C=C\CCCC(O)​=O)​C=C1)​C1=O
InCHI Code
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​1S/C20H30O4/c1-2-3-6-10-17(21)​13-14-18-16(12-15-19(18)​22)​9-7-4-5-8-11-20(23)​24/h4,7,12-18,21H,2-3,5-6,8-11H2,1H3,(H,23,24)​/b7-4-,14-13+/t16-,17-,18+/m0/s1
InCHI Key
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UQOQENZZLBSFKO-POPPZSFYSA-N

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Prostaglandin J2 is available in the following screening libraries:

Size Price Quantity Subtotal
500 µg $65.00 $0.00
1 mg $124.00 $0.00
5 mg $520.00 $0.00
10 mg $910.00 $0.00
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Pricing updated 2014-04-20. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Prostaglandin J2 Lipid Maps MS Standard
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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

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Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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