Prostaglandin J2 (PGJ2) is formed from PGD2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.1 PGJ2 inhibits platelet aggregation with an IC50 of about 5-10 nM.2,3 PGJ2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.4 However, this activity has been attributed to further metabolites of PGJ2 and not the parent compound itself.
1Fitzpatrick, F.A., and Wynalda, M.A.Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro. J Biol Chem25811713-11718(1983).
2Bundy, G.L., Morton, D.R., Peterson, D.C., et al. Synthesis and platelet aggregation inhibiting activity of prostaglandin D analogues. J Med Chem26790-799(1983).
3Mahmud, I., Smith, D.L., Whyte, M.A., et al. On the identification and biological properties of prostaglandin J2. Prostaglandins Leukot Med16131-146(1984).
4Fukushima, M.Prostaglandin J2 - antitumor and anti-viral activities and the mechanisms involved. Eicosanoids3189-199(1990).
Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.
Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.
Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.
Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research
Analytical testing services and custom synthesis also available