Cayman Chemical Item Number 18590

9,10-dihydro-15-deoxy-Δ12,14-PGJ2; 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2 (CAS 596104-94-8)

See more


CAY10410 is an analog of prostaglandin D2/prostaglandin J2 (PGD2/PGJ2) with structural modifications intended to give it PPARγ ligand activity and resistance to metabolism. 15-deoxy-Δ12,14-PGJ2 has been shown to be a potent ligand for PPARγ.1 Metabolism of the cyclopentenone prostaglandins PGA2, PGJ2, and Δ12-PGJ2 occurs via glutathione addition across the α,β unsaturated enone.2 CAY10410 was designed as an analog of the PPARγ-binding prostaglandins which could not undergo this conjugation reaction. In human neuroblastoma SH-SY5Y cells, CAY10410 was not cytotoxic at up to 25 µM. It also failed to covalently modify thioredoxin or induce oxidative stress at 50 µM.3

1. Forman, B.M., Tontonoz, P., Chen, J., et al. 15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ. Cell 83 803-812 (1995).

2. Atsmon, J., Sweetman, B.J., Baertschi, S.W., et al. Formation of thiol conjugates of 9-deoxy-Δ912(E)-prostaglandin D2 and Δ12(E)-prostaglandin D2. Biochemistry 29 3760-3765 (1990).

3. Shibata, T., Yamada, T., Ishii, T., et al. Thioredoxin as a molecular target of cyclopentenone prostaglandins. J Biol Chem 278(28) 26046-26054 (2003).

  • 9,10-dihydro-15-deoxy-Δ12,14-PGJ2
  • 9,10-dihydro-15-deoxy-Δ12,14-Prostaglandin J2
Formal Name 11-​oxo-​prosta-​5Z,​12E,​14Z-​trien-​1-​oic acid
CAS Number 596104-94-8
Molecular Formula C20H30O3
Formula Weight 318.5
Formulation A solution in methyl acetate
Purity ≥98% (isomer mixture)
λmax 293 nm
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Copy SMILES to clipboard
InCHI Code
Copy InCHI code to clipboard
Copy InCHI key to clipboard

Download free InCHI Key generation software

CAY10410 is available in the following screening library:

Size Price Quantity Subtotal
500 µg $70.00 $0.00
1 mg $133.00 $0.00
5 mg $560.00 $0.00
10 mg $980.00 $0.00
Bulk Contact
Cart Total $0.00

Pricing updated 2015-07-31. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

15-deoxy-Δ12,14-Prostaglandin J2
15-deoxy-Δ12,14-Prostaglandin J2-biotin
Prostaglandin D2


Batch-specific Information

Get batch-specific data and documents by batch number

Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

Cayman Chemical

1180 East Ellsworth Road

Ann Arbor, Michigan 48108 USA


Please wait...