Pinane Thromboxane A2

Cayman Chemical Item Number 19020

Pinane TXA2; PTA2 (CAS 71111-01-8)

Pinane Thromboxane A2 (CAS 71111-01-8)

See more

Description

PTA2 is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase.1,2 PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.1

1 Nicolaou, K.C., Magolda, R.L., Smith, J.B., et al. Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. Proc Natl Acad Sci USA 76 2566-2570 (1979).

2 Schrör, K., Smith, E.F., Bickerton, M., et al. Preservation of ischemic myocardium by pinane thromboxane A2. Am J Physiol 238 H87-H92 (1980).

Synonyms
  • Pinane TXA2
  • PTA2
Formal Name 9α,​11α-​(dimethyl)methylene-​15S-​hydroxy-​11a-​deoxy-​11a-​methylene-​thromba-​5Z,​13E-​dien-​1-​oic
CAS Number 71111-01-8
Molecular Formula C24H40O3
Formula Weight 376.6
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
SMILES
Copy SMILES to clipboard
CCCCC[C@H]​(O)​/C=C/[C@H]​1C[C@H]​2C[C@H]​(C2(C)​C)​[C@@H]​1C/C=C\CCCC(O)​=O
InCHI Code
Copy InCHI code to clipboard
​1S/C24H40O3/c1-4-5-8-11-20(25)​15-14-18-16-19-17-22(24(19,2)​3)​21(18)​12-9-6-7-10-13-23(26)​27/h6,9,14-15,18-22,25H,4-5,7-8,10-13,16-17H2,1-3H3,(H,26,27)​/b9-6-,15-14+/t18-,19-,20-,21+,22-/m0/s1
InCHI Key
Copy InCHI key to clipboard
OHJIHGVLRDHSDV-BNAVIEMTSA-N

Download free InCHI Key generation software

Size Price Quantity Subtotal
500 µg $43.00 $0.00
1 mg $82.00 $0.00
5 mg $344.00 $0.00
10 mg $602.00 $0.00
Bulk Contact
Cart Total $0.00

Please Login or Register to use this page.

Pricing updated 2014-04-16. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

Related Products

15(R)-Pinane Thromboxane A2
BAY-u3405
BM 567
Carbocyclic Thromboxane A2
SQ 29,548
Show all 5 Hide all but first 3

Downloads

Batch-specific Information

Get batch-specific data and documents by batch number


Separate multiple batch numbers with commas

Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

See personalized New Product recommendations! Get personalized New Product recommendations! Register or Login for personalized New Product recommendations!

Other Resources
About Cayman Management Team Company Profile ChemAssistant Tools FAQs Cayman Europe Cayman Pharma CaBRI Cayman Gear Press Releases Illustrations and Charts Key Research Area Posters Article Library Analysis Tools Conference Schedule Order Terms Browser Recommendation Privacy Statement Site Map Conference Travel Grants

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2014 Cayman Chemical Company

Manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research · Buy now! · Analytical testing services and custom synthesis also available

Lost password?