Pinane Thromboxane A2

Cayman Chemical Item Number 19020

Pinane TXA2; PTA2 (CAS 71111-01-8)

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PTA2 is a stable analog of TXA2. It is a TP receptor antagonist and an inhibitor of thromboxane synthase.1,2 PTA2 inhibits U-46619-induced cat coronary artery constriction (ID50 = 0.1 µM), U-46619-induced aggregation of human platelets (IC50 = 2 µM), and rabbit platelet thromboxane synthase (ID50 = 50 µM). PTA2 does not affect PGI synthase up to a concentration of 100 µM.1

1. Nicolaou, K.C., Magolda, R.L., Smith, J.B., et al. Synthesis and biological properties of pinane-thromboxane A2, a selective inhibitor of coronary artery constriction, platelet aggregation, and thromboxane formation. Proc Natl Acad Sci USA 76 2566-2570 (1979).

2. Schrör, K., Smith, E.F., Bickerton, M., et al. Preservation of ischemic myocardium by pinane thromboxane A2. Am J Physiol 238 H87-H92 (1980).

  • Pinane TXA2
  • PTA2
Formal Name 9α,​11α-​(dimethyl)methylene-​15S-​hydroxy-​11a-​deoxy-​11a-​methylene-​thromba-​5Z,​13E-​dien-​1-​oic
CAS Number 71111-01-8
Molecular Formula C24H40O3
Formula Weight 376.6
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Wet ice in continental US; may vary elsewhere
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Size Price Quantity Subtotal
500 µg $43.00 $0.00
1 mg $82.00 $0.00
5 mg $344.00 $0.00
10 mg $602.00 $0.00
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