SQ 29,548
Item № 19025
CAS № 98672-91-4
Purity ≥98%
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1 mg $65.00 $0.00
5 mg $293.00 $0.00
10 mg $520.00 $0.00

Pricing updated 2015-11-25. Prices are subject to change without notice.

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SQ 29,548 is a highly selective TP receptor antagonist which binds to the human recombinant TP receptor with a Ki of 4.1 nM.1 It inhibits the aggregation of washed human platelets induced by U-46619 with an IC50 of 0.06 µM.2 It antagonizes U-46619 induced contraction of rat and guinea pig tracheal, arterial, and venous smooth muscles with drug/receptor dissociation constants (KB) in the range of 0.5-1.7 nM.3 SQ 29,548 also inhibits the contraction of rat vascular smooth muscle induced by 8-iso PGF.4

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Technical Information
Formal Name [1S-[1α,2α(Z),3α,4α]]-7-[3-[[2-[(phenylamino)carbonyl]hydrazino]methyl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid
CAS Number 98672-91-4
Molecular Formula C21H29N3O4
Formula Weight 387.5
Purity ≥98%
Formulation A crystalline solid
InChI Code 1S/C21H29N3O4/c25-20(26)11-7-2-1-6-10-16-17(19-13-12-18(16)28-19)14-22-24-21(27)23-15-8-4-3-5-9-15/h1,3-6,8-9,16-19,22H,2,7,10-14H2,(H,25,26)(H2,23,24,27)/b6-1-

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
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References & Background Reading
Product Description References

1. Abramovitz, M., Adam, M., Boie, Y., et al. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim Biophys Acta 1483 285-293 (2000).

2. Ogletree, M.L., Harris, D.N., Greenberg, R., et al. Pharmacological actions of SQ 29,548, a novel selective thromboxane antagonist. J Pharmacol Exp Ther 234 435-441 (1985).

3. Ogletree, M.L., and Allen, G.T. Interspecies differences in thromboxane receptors: Studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J Pharmacol Exp Ther 260 789-794 (1992).

4. Fukunaga, M., Makita, N., Roberts, L.J., et al. Evidence for the existence of F2-isoprostane receptors on rat vascular smooth muscle cells. Am J Physiol 264 C1619-C1624 (1993).

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