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Cayman is a manufacturer, supplier, and vendor of biochemical reagents, assay kits, forensic chemistry standards, antibodies, and proteins for scientific research. Analytical testing services and custom synthesis are also available.

Cayman Chemical Company · 1180 East Ellsworth Road · Ann Arbor, Michigan 48108 · USA

Toll Free: (800) 364-9897 (USA and Canada Only) · Fax: (734) 971-3640

Copyright 2015 Cayman Chemical Company

CD36 Blocking Peptide

Cayman Chemical Item Number 300011

GPIIIb; GPIV; Hexarelin Receptor; oxLDL Receptor; Thrombospondin Receptor

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Description

Peptide sequence: human CD36 sequence amino acids 98-114 (AKENVTQDAEDNTVSF) · To be used in conjunction with Cayman’s CD36 polyclonal antibody (Catalog No. 100011) to block protein-antibody complex formation during immunochemical analysis of CD36. · CD36 is a type-B scavenger receptor that is necessary for the formation of foam cells in atherosclerotic lesions.1,2,3,4 This membrane glycoprotein can internalize fatty acids which activate PPARγ and stimulate further expression of CD36.5,6 This positive feedback loop combined with the murine CD36 knock-out studies reinforces the importance of CD36 in lipid metabolism. Additionally CD36 is needed for the phagocytosis of P. falciparum infected erythrocytes, retinal pigment epithelial cell photoreceptor fragments, and post-apoptotic monocytes and neutrophils.7,8,9,10 CD36 expression has been monitored during hematopoietic cell differentiation and may be an indicator of tumor spreading in lymphocytic leukemia.11 This transmembrane glycoprotein is detected by immunoblotting at 88 kDa or 54 kDa depending on the degree of glycosylation of the receptor in your sample. Positive controls include adipose and heart tissue, platelets, and macrophages.

1. Febbraio, M., Abumrad, N.A., Hajjar, D.P., et al. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. J Biol Chem 274 19055-19062 (1999).

2. Podrez, E.A., Febbraio, M., Sheibani, N., et al. Macrophage scavenger receptor CD36 is the major receptor for LDL modified by monocyte-generated reactive nitrogen species. J Clin Invest 105(8) 1095-1108 (2000).

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4. Febbraio, M., Hajjar, D.P., and Silverstein, R.L. CD36: A class B scavenger receptor involved in angiogenesis, atherosclerosis, inflammation, and lipid metabolism. J Clin Invest 108(6) 785-791 (2001).

5. Han, J., Hajjar, D.P., Febbraio, M., et al. Native and modified low density lipoproteins increase the functional expression of the macrophage class B scavenger receptor, CD36. J Biol Chem 272(34) 21654-21659 (1997).

6. Tontonoz, P., Nagy, L., Alvarez, J.G.A., et al. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93 241-252 (1998).

7. Greenwalt, D.E., Lipsky, R.H., Ockenhouse, C.F., et al. Membrane glycoprotein CD36: A review of its roles in adherence, signal transduction, and transfusion medicine. Blood 80(5) 1105-1115 (1992).

8. Finnemann, S.C., and Silverstein, R.L. Differential roles of CD36 and αvβ5 integrin in photoreceptor phagocytosis by the retinal pigment epithelium. J Exp Med 194(9) 1289-1298 (2001).

9. Navazo, M.D.P., Daviet, L., Savill, J., et al. Identification of a domain (155-183) on CD36 implicated in the phagocytosis of apoptotic neutrophils. J Biol Chem 271(26) 15381-15385 (1996).

10. Jiménez, B., Volpert, O.V., Crawford, S.E., et al. Signals leading to apoptosis-dependent inhibition of neovascularization by thrombospondin-1. Nat Med 6(1) 41-48 (2000).

11. Rutella, S., Rumi, C., Puggioni, P., et al. Expression of thrombospondin receptor (CD36) in B-cell chronic lymphocytic leukemia as an indicator of tumor cell dissemination. Haematologica 84 419-424 (1999).

Synonyms
  • GPIIIb
  • GPIV
  • Hexarelin Receptor
  • oxLDL Receptor
  • Thrombospondin Receptor
Formulation 200 µg lyophilized peptide
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere

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Size Price Quantity Subtotal
1 ea $107.00 $0.00
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Pricing updated 2015-03-04. Prices are subject to change without notice.

To ask for assistance with one of our products please contact a Technical Support Scientist.

Warning This product is not for human or veterinary use.

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Cayman Chemical Company regularly evaluates our shipping methods to ensure product stability is maintained and our corporate environmental impact is minimized. Products selected for review are evaluated and shipping methods are certified by our Scientists. While occasionally our method of shipping a product may change, rest assured the shipping conditions on all Cayman Chemical products have been reviewed and validated.

Upon receipt, it is important to check the storage requirements of your products and place them at the appropriate temperature. Products shipped without ice may require frozen storage for long term stability.

Cayman Chemical was formed over thirty years ago by demonstrating the value of naturally growing gorgonian corals as a renewable, economically viable source of prostaglandins. Today we operate our business knowing that we owe our start to the renewable resources our environment had provided. As Cayman Chemical continues to grow we consistently evaluate our business processes to ensure we are operating at the highest environmental standards.

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