PAF C-16

Cayman Chemical Item Number 60900

Platelet-activating Factor C-16 (CAS 74389-68-7)

PAF C-16 (CAS 74389-68-7)

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Description

PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways.1 It is a potent mediator of neutrophil migration,2 and the production of reactive oxygen species, and IL-6 in human macrophages.3,4 It is a more potent mediator of platelet aggregation than PAF C-18.5 Pathological processes involving PAF include necrotizing enterocolitis,6 inflammation, asthma, and allergy.7

1 Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

2 Carolan, E.J., and Casale, T.B. Degree of platelet activating factor-induced neutrophil migration is dependent upon the molecular species. J Immunol 145 2561-2565 (1990).

3 Rouis, M., Nigon, F., and Chapman, M.J. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochem Biophys Res Commun 156 1293-1301 (1988).

4 Thivierge, M., and Rola-Pleszczynski, M. Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. J Allergy Clin Immunol 90 796-802 (1992).

5 Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

6 Wang, H., Tan, X., Qu, X., et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximide. Pediatr Res 42 597-603 (1997).

7 Sturk, A., Wouter Ten Cate, J., Hosford, D., et al. The synthesis, catabolism, and pathophysiological role of platelet-activating factor. Adv Lipid Res 23 219-276 (1989).

Synonyms
  • Platelet-activating Factor C-16
Formal Name 1-​O-​hexadecyl-​2-​O-​acetyl-​sn-​glyceryl-​3-​phosphorylcholine
CAS Number 74389-68-7
Molecular Formula C26H54NO7P
Formula Weight 523.7
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCOC[C@@H]​(OC(C)​=O)​COP(OCC[N+]​(C)​(C)​C)​([O-]​)​=O
InCHI Code
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​1S/C26H54NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-31-23-26(34-25(2)​28)​24-33-35(29,30)​32-22-20-27(3,4)​5/h26H,6-24H2,1-5H3/t26-/m1/s1
InCHI Key
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HVAUUPRFYPCOCA-AREMUKBSSA-N

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Size Price Quantity Subtotal
5 mg $50.00 $0.00
10 mg $95.00 $0.00
50 mg $400.00 $0.00
100 mg $700.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-21. Prices are subject to change without notice.

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