2-O-methyl PAF C-16

Cayman Chemical Item Number 60902

(CAS 78858-44-3)

2-O-methyl PAF C-16 (CAS 78858-44-3)

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Description

2-O-methyl PAF C-16 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. Although the biological activities of 2-O-methyl PAF C-16 have not been well characterized, the C-18 analog has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart.1 In rat astrocytes, the C-18 analog causes the release of large quantities of NO by a pathway involving activation of NOS.2

1 van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22 820-823 (1987).

2 Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Res 715 98-103 (1996).

Formal Name 1-​O-​hexadecyl-​2-​O-​methyl-​sn-​glyceryl-​3-​phosphorylcholine
CAS Number 78858-44-3
Molecular Formula C25H54NO6P
Formula Weight 495.7
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCOC[C@@H]​(OC)​COP(OCC[N+]​(C)​(C)​C)​([O-]​)​=O
InCHI Code
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​1S/C25H54NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-30-23-25(29-5)​24-32-33(27,28)​31-22-20-26(2,3)​4/h25H,6-24H2,1-5H3
InCHI Key
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RZNRKXGAJMGLIM-UHFFFAOYSA-N

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2-O-methyl PAF C-16 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $46.00 $0.00
10 mg $87.00 $0.00
50 mg $368.00 $0.00
100 mg $644.00 $0.00
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Pricing updated 2014-04-21. Prices are subject to change without notice.

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