2-O-methyl PAF C-16

Cayman Chemical Item Number 60902

(CAS 78858-44-3)

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2-O-methyl PAF C-16 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. Although the biological activities of 2-O-methyl PAF C-16 have not been well characterized, the C-18 analog has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart.1 In rat astrocytes, the C-18 analog causes the release of large quantities of NO by a pathway involving activation of NOS.2

1. van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22 820-823 (1987).

2. Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Res 715 98-103 (1996).

Formal Name 1-​O-​hexadecyl-​2-​O-​methyl-​sn-​glyceryl-​3-​phosphorylcholine
CAS Number 78858-44-3
Molecular Formula C25H54NO6P
Formula Weight 495.7
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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2-O-methyl PAF C-16 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $46.00 $0.00
10 mg $87.00 $0.00
50 mg $368.00 $0.00
100 mg $644.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-02. Prices are subject to change without notice.

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Related Products

PAF C-16
PAF C-16 Carboxylic Acid


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