Hexanolamino PAF C-16

Cayman Chemical Item Number 60905

(CAS 137566-83-7)

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Description

Hexanolamino PAF C-16 is a PAF analog with mixed agonist/antagonist properties. In human monocyte-derived macrophages, it is an antagonist which inhibits the production of reactive oxygen species in response to PAF C-16.1 On the other hand, in rabbit platelets and guinea pig macrophages, hexanolamino PAF C-16 is a partial agonist, and in guinea pig platelets it is a full agonist.2

1. Rouis, M., Nigon, F., and Chapman, M.J. Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. Biochem Biophys Res Commun 156 1293-1301 (1988).

2. Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

Formal Name 1-​O-​hexadecyl-​2-​O-​acetyl-​sn-​glyceryl-​3-​phosphoryl(N,​N,​N-​trimethyl)hexanolamine
CAS Number 137566-83-7
Molecular Formula C30H62NO7P
Formula Weight 579.8
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCOC[C@@H]​(OC(C)​=O)​COP(OCCCCCC[N+]​(C)​(C)​C)​([O-]​)​=O
InCHI Code
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​1S/C30H62NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-19-22-25-35-27-30(38-29(2)​32)​28-37-39(33,34)​36-26-23-20-18-21-24-31(3,4)​5/h30H,6-28H2,1-5H3/t30-/m1/s1
InCHI Key
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IJAODKNFSHBTDQ-SSEXGKCCSA-N

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Hexanolamino PAF C-16 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $21.00 $0.00
5 mg $95.00 $0.00
10 mg $168.00 $0.00
25 mg $368.00 $0.00
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PAF C-16

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