Methylcarbamyl PAF C-16

Cayman Chemical Item Number 60908

(CAS 91575-58-5)

Methylcarbamyl PAF C-16 (CAS 91575-58-5)

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Description

Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.1,2 It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.1 In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase.2 Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.2

1 Hadváry, P., Cassal, J., Hirth, G., et al. Structural requirements for the activation of blood platelets by analogues of platelet-activating factor (PAF-acether). Platelet-Activating Factor INSERM Symposium 23 57-64 (1983).

2 Kume, K., and Shimizu, T. Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. J Biol Chem 272 22898-22904 (1997).

Formal Name 1-​O-​hexadecyl-​2-​O-​(N-​methylcarbamoyl)-​sn-​glyceryl-​3-​phosphorylcholine
CAS Number 91575-58-5
Molecular Formula C26H55N2O7P
Formula Weight 538.7
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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CCCCCCCCCCCCCCCCOC[C@@H]​(OC(NC)​=O)​COP(OCC[N+]​(C)​(C)​C)​([O-]​)​=O
InCHI Code
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​1S/C26H55N2O7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-32-23-25(35-26(29)​27-2)​24-34-36(30,31)​33-22-20-28(3,4)​5/h25H,6-24H2,1-5H3,(H-,27,29,30,31)​/t25-/m1/s1
InCHI Key
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FNFHZBKBDFRYHS-RUZDIDTESA-N

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Methylcarbamyl PAF C-16 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $32.00 $0.00
5 mg $144.00 $0.00
10 mg $256.00 $0.00
25 mg $560.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-18. Prices are subject to change without notice.

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