Methylcarbamyl PAF C-16
Item № 60908
CAS № 91575-58-5
Purity ≥98%
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1 mg $32.00 $0.00
5 mg $144.00 $0.00
10 mg $256.00 $0.00
25 mg $560.00 $0.00

Pricing updated 2015-11-26. Prices are subject to change without notice.

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Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.1,2 It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.1 In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase.2 Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.2

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Technical Information
Formal Name 1-O-hexadecyl-2-O-(N-methylcarbamoyl)-sn-glyceryl-3-phosphorylcholine
CAS Number 91575-58-5
Molecular Formula C26H55N2O7P
Formula Weight 538.7
Purity ≥98%
Formulation A solution in ethanol
InChI Code 1S/C26H55N2O7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-21-32-23-25(35-26(29)27-2)24-34-36(30,31)33-22-20-28(3,4)5/h25H,6-24H2,1-5H3,(H-,27,29,30,31)/t25-/m1/s1

WARNING - This product is not for human or veterinary use.

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Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
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Download Safety Data Sheet (SDS) 28 Kb PDF

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References & Background Reading
Product Description References

1. Hadváry, P., Cassal, J., Hirth, G., et al. Structural requirements for the activation of blood platelets by analogues of platelet-activating factor (PAF-acether). Platelet-Activating Factor INSERM Symposium 23 57-64 (1983).

2. Kume, K., and Shimizu, T. Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. J Biol Chem 272 22898-22904 (1997).

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