Methylcarbamyl PAF C-16

Cayman Chemical Item Number 60908

(CAS 91575-58-5)

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Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH.1,2 It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma.1 In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase.2 Methylcarbamyl PAF C-16 induces G1 phase cell cycle arrest, suggesting a potential role for PAF in the inhibition of oncogenic transformation.2

1. Hadváry, P., Cassal, J., Hirth, G., et al. Structural requirements for the activation of blood platelets by analogues of platelet-activating factor (PAF-acether). Platelet-Activating Factor INSERM Symposium 23 57-64 (1983).

2. Kume, K., and Shimizu, T. Platelet-activating factor (PAF) induces growth stimulation, inhibition, and suppression of oncogenic transformation in NRK cells overexpressing the PAF receptor. J Biol Chem 272 22898-22904 (1997).

Formal Name 1-​O-​hexadecyl-​2-​O-​(N-​methylcarbamoyl)-​sn-​glyceryl-​3-​phosphorylcholine
CAS Number 91575-58-5
Molecular Formula C26H55N2O7P
Formula Weight 538.7
Formulation A solution in ethanol
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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Methylcarbamyl PAF C-16 is available in the following screening library:

Size Price Quantity Subtotal
1 mg $32.00 $0.00
5 mg $144.00 $0.00
10 mg $256.00 $0.00
25 mg $560.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-05. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Ann Arbor, Michigan 48108 USA


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