PAF C-18

Cayman Chemical Item Number 60910

(CAS 74389-69-8)

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PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the “remodeling” and 'de novo' pathways.1 It is less potent than PAF C-16 in the induction of platelet aggregation, but equipotent in activation of guinea pig macrophages.2 PAF C-18 induces the release of PGE2 and TXB2 from albumin-elicited guinea pig macrophages, and enhances the spreading of plated macrophages.3 Pathological processes involving PAF include necrotizing enterocolitis,4 inflammation, asthma, and allergy.5

1. Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

2. Stewart, A.G., and Grigoriadis, G. Structure-activity relationships for platelet-activating factor (PAF) and analogs reveal differences between PAF receptors on platelets and macrophages. J Lipid Mediat 4 299-308 (1991).

3. Hartung, H. Acetyl glyceryl ether phosphorylcholine (platelet-activating factor) mediates heightened metabolic activity in macrophages. Studies on PGE, TXB2 and O2 production, spreading, and the influence of calmodulin-inhibitor W-7. FEBS Lett 160 209-212 (1983).

4. Wang, H., Tan, X., Qu, X., et al. Platelet-activating factor (PAF) up-regulates plasma and tissue PAF-acetylhydrolase activity in the rat: Effect of cycloheximide. Pediatr Res 42 597-603 (1997).

5. Sturk, A., Wouter Ten Cate, J., Hosford, D., et al. The synthesis, catabolism, and pathophysiological role of platelet-activating factor. Adv Lipid Res 23 219-276 (1989).

Formal Name 1-​O-​octadecyl-​2-​O-​acetyl-​sn-​glyceryl-​3-​phosphorylcholine
CAS Number 74389-69-8
Molecular Formula C28H58NO7P
Formula Weight 551.7
Formulation A solution in ethanol
Purity ≥97%
Stability 2 years
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
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PAF C-18 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $50.00 $0.00
10 mg $95.00 $0.00
50 mg $400.00 $0.00
100 mg $700.00 $0.00
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Cart Total $0.00

Pricing updated 2015-08-05. Prices are subject to change without notice.

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Warning This product is not for human or veterinary use.

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Ann Arbor, Michigan 48108 USA


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