2-O-methyl PAF C-18
Item № 60912
CAS № 77286-66-9
Purity ≥98%
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5 mg $42.00 $0.00
10 mg $80.00 $0.00
50 mg $336.00 $0.00
100 mg $571.00 $0.00

Pricing updated 2015-11-29. Prices are subject to change without notice.

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  • 1-O-octadecyl-2-O-methyl-sn-glyceryl-3-phosphorylcholine
  • ET-18-OCH3
  • Edelfosine

2-O-methyl-PAF C-18 is a synthetic PAF analog which contains a methyl group, attached by an ether linkage, at the sn-2 position. It has been shown to mediate a number of biological responses including decreasing plasma membrane fluidity and inhibiting tumor cell invasiveness in embryonic chick heart.1 In rat astrocytes, 2-O-methyl PAF C-18 causes the release of large quantities of nitric oxide by a pathway involving activation of nitric oxide synthase.2

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Technical Information
Formal Name 3,5,9-trioxa-4-phosphaheptacosan-1-aminium, 4-hydroxy-7R-methoxy-N,N,N-trimethyl-4-oxide
CAS Number 77286-66-9
  • 1-O-octadecyl-2-O-methyl-sn-glyceryl-3-phosphorylcholine
  • ET-18-OCH3
  • Edelfosine
Molecular Formula C27H58NO6P
Formula Weight 523.7
Purity ≥98%
Formulation A lyophilized powder
InChI Code 1S/C27H58NO6P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-32-25-27(31-5)26-34-35(29,30)33-24-22-28(2,3)4/h27H,6-26H2,1-5H3

WARNING - This product is not for human or veterinary use.

Shipping & Storage
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
Stability 1 year
Product Downloads & Resources
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Download Product Insert 151 Kb PDF

Download Safety Data Sheet (SDS) 23 Kb PDF

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Additional Information

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References & Background Reading
Product Description References

1. van Blitterswijk, W.J., Hilkmann, H., and Storme, G.A. Accumulation of an alkyl lysophospholipid in tumor cell membranes affects membrane fluidity and tumor cell invasion. Lipids 22 820-823 (1987).

2. Cardile, V., Jiang, X., Renis, M., et al. Effects of ether lipid 1-O-octadecyl-2-methoxy-rac-glycero-3-phosphocholine and its analogs PAF and CPAF on the release of nitric oxide in primary cultures of rat astrocytes. Brain Res 715 98-103 (1996).

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