Lyso-PAF C-18

Cayman Chemical Item Number 60916

(CAS 74430-89-0)

Lyso-PAF C-18 (CAS 74430-89-0)

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Description

Lyso-PAF C-18 can be formed by either the action of PAF-AH on PAF C-181 or by the action of a CoA-independent transacylase on 1-O-octadecyl-2-acyl-glycerophosphocholine.2,3 Lyso PAF C-18 is a substrate for either PAF C-18 formation by the remodeling pathway4 or selective acylation with arachidonic acid by a CoA-independent transacylase.5

1 Stafforini, D.M., Prescott, S.M., and McIntyre, T.M. Human plasma platelet-activating factor acetylhydrolase. J Biol Chem 262 4223-4230 (1987).

2 Uemura, Y., Lee, T., and Snyder, F. A coenzyme A-independent transacylase is linked to the formation of platelet-activating factor (PAF) by generating the lyso-PAF intermediate in the remodeling pathway. J Biol Chem 266 8268-8272 (1991).

3 Venable, M.E., Nieto, M.L., Schmitt, J.D., et al. Conversion of 1-O-[3H]alkyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine to lyso platelet-activating factor by the CoA-independent transacylase in membrane fractions of human neutrophils. J Biol Chem 266 18691-18698 (1991).

4 Prescott, S.M., Zimmerman, G.A., and McIntyre, T.M. Platelet-activating factor. J Biol Chem 265 17381-17384 (1990).

5 Venable, M.E., Olson, S.C., Nieto, M.L., et al. Enzymatic studies of lyso platelet-activation factor acylation in human neutrophils and changes upon stimulation. J Biol Chem 268 7965-7975 (1993).

Formal Name 1-​O-​octadecyl-​sn-​glyceryl-​3-​phosphorylcholine
CAS Number 74430-89-0
Molecular Formula C26H56NO6P
Formula Weight 509.7
Formulation A lyophilized powder
Purity ≥98%
Stability 1 year
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere
SMILES
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O=P(OCC[N+]​(C)​(C)​C)​([O-]​)​OC[C@H]​(O)​COCCCCCCCCCCCCCCCCCC
InCHI Code
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​1S/C26H56NO6P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-22-31-24-26(28)​25-33-34(29,30)​32-23-21-27(2,3)​4/h26,28H,5-25H2,1-4H3/t26-/m1/s1
InCHI Key
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XKBJVQHMEXMFDZ-AREMUKBSSA-N

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Lyso-PAF C-18 is available in the following screening library:

Size Price Quantity Subtotal
5 mg $40.00 $0.00
10 mg $72.00 $0.00
50 mg $240.00 $0.00
100 mg $384.00 $0.00
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Cart Total $0.00

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Pricing updated 2014-04-20. Prices are subject to change without notice.

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